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Lipid flippase dysfunction as a novel therapeutic target for endosomal anomalies in Alzheimer’s disease

Nanaka Kaneshiro, Masato Komai, Ryosuke Imaoka, Atsuya Ikeda, Yuji Kamikubo, Tadafumi Hashimoto, Takeshi Iwatsubo, Takashi Sakurai, Takashi Uehara, View ORCID ProfileNobumasa Takasugi
doi: https://doi.org/10.1101/2021.07.30.454423
Nanaka Kaneshiro
1Department of Medicinal Pharmacology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, 1-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan
2Research Fellow of Japan Society for the Promotion of Science, Chiyoda-ku, Tokyo 102-0083, Japan
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Masato Komai
1Department of Medicinal Pharmacology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, 1-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan
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Ryosuke Imaoka
1Department of Medicinal Pharmacology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, 1-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan
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Atsuya Ikeda
1Department of Medicinal Pharmacology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, 1-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan
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Yuji Kamikubo
4Department of Cellular and Molecular Pharmacology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan
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Tadafumi Hashimoto
3Department of Neuropathology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan
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Takeshi Iwatsubo
3Department of Neuropathology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan
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Takashi Sakurai
4Department of Cellular and Molecular Pharmacology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan
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Takashi Uehara
1Department of Medicinal Pharmacology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, 1-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan
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Nobumasa Takasugi
1Department of Medicinal Pharmacology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, 1-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan
4Department of Cellular and Molecular Pharmacology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan
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  • ORCID record for Nobumasa Takasugi
  • For correspondence: ntakasu@okayama-u.ac.jp
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Article Information

doi 
https://doi.org/10.1101/2021.07.30.454423
History 
  • August 29, 2021.

Article Versions

  • Version 1 (July 30, 2021 - 21:37).
  • Version 2 (August 17, 2021 - 03:16).
  • You are viewing Version 3, the most recent version of this article.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

Author Information

  1. Nanaka Kaneshiro1,2,
  2. Masato Komai1,
  3. Ryosuke Imaoka1,
  4. Atsuya Ikeda1,
  5. Yuji Kamikubo4,
  6. Tadafumi Hashimoto3,
  7. Takeshi Iwatsubo3,
  8. Takashi Sakurai4,
  9. Takashi Uehara1 and
  10. Nobumasa Takasugi1,4,*
  1. 1Department of Medicinal Pharmacology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, 1-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan
  2. 2Research Fellow of Japan Society for the Promotion of Science, Chiyoda-ku, Tokyo 102-0083, Japan
  3. 3Department of Neuropathology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan
  4. 4Department of Cellular and Molecular Pharmacology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan
  1. ↵* Correspondence should be addressed to - Nobumsa Takasugi, Ph.D., Department of Medicinal Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8530, Japan, email: ntakasu{at}okayama-u.ac.jp, tel & fax+81-86-251-7985
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Posted August 29, 2021.
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Lipid flippase dysfunction as a novel therapeutic target for endosomal anomalies in Alzheimer’s disease
Nanaka Kaneshiro, Masato Komai, Ryosuke Imaoka, Atsuya Ikeda, Yuji Kamikubo, Tadafumi Hashimoto, Takeshi Iwatsubo, Takashi Sakurai, Takashi Uehara, Nobumasa Takasugi
bioRxiv 2021.07.30.454423; doi: https://doi.org/10.1101/2021.07.30.454423
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Lipid flippase dysfunction as a novel therapeutic target for endosomal anomalies in Alzheimer’s disease
Nanaka Kaneshiro, Masato Komai, Ryosuke Imaoka, Atsuya Ikeda, Yuji Kamikubo, Tadafumi Hashimoto, Takeshi Iwatsubo, Takashi Sakurai, Takashi Uehara, Nobumasa Takasugi
bioRxiv 2021.07.30.454423; doi: https://doi.org/10.1101/2021.07.30.454423

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