Lipid flippase dysfunction as a novel therapeutic target for endosomal anomalies in Alzheimer’s disease

Nanaka Kaneshiro; Masato Komai; Ryosuke Imaoka; Atsuya Ikeda; Yuji Kamikubo; Tadafumi Hashimoto; Takeshi Iwatsubo; Takashi Sakurai; Takashi Uehara; Nobumasa Takasugi

doi:10.1101/2021.07.30.454423

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Lipid flippase dysfunction as a novel therapeutic target for endosomal anomalies in Alzheimer’s disease

Nanaka Kaneshiro, Masato Komai, Ryosuke Imaoka, Atsuya Ikeda, Yuji Kamikubo, Tadafumi Hashimoto, Takeshi Iwatsubo, Takashi Sakurai, Takashi Uehara, View ORCID ProfileNobumasa Takasugi

doi: https://doi.org/10.1101/2021.07.30.454423

Nanaka Kaneshiro

1Department of Medicinal Pharmacology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, 1-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan

2Research Fellow of Japan Society for the Promotion of Science, Chiyoda-ku, Tokyo 102-0083, Japan

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Masato Komai

1Department of Medicinal Pharmacology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, 1-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan

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Ryosuke Imaoka

1Department of Medicinal Pharmacology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, 1-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan

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Atsuya Ikeda

1Department of Medicinal Pharmacology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, 1-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan

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Yuji Kamikubo

4Department of Cellular and Molecular Pharmacology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan

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Tadafumi Hashimoto

3Department of Neuropathology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan

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Takeshi Iwatsubo

3Department of Neuropathology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan

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Takashi Sakurai

4Department of Cellular and Molecular Pharmacology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan

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Takashi Uehara

1Department of Medicinal Pharmacology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, 1-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan

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Nobumasa Takasugi

1Department of Medicinal Pharmacology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, 1-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan

4Department of Cellular and Molecular Pharmacology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan

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ORCID record for Nobumasa Takasugi
For correspondence: ntakasu@okayama-u.ac.jp

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Posted August 29, 2021.

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Lipid flippase dysfunction as a novel therapeutic target for endosomal anomalies in Alzheimer’s disease

Nanaka Kaneshiro, Masato Komai, Ryosuke Imaoka, Atsuya Ikeda, Yuji Kamikubo, Tadafumi Hashimoto, Takeshi Iwatsubo, Takashi Sakurai, Takashi Uehara, Nobumasa Takasugi

bioRxiv 2021.07.30.454423; doi: https://doi.org/10.1101/2021.07.30.454423

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Lipid flippase dysfunction as a novel therapeutic target for endosomal anomalies in Alzheimer’s disease

Nanaka Kaneshiro, Masato Komai, Ryosuke Imaoka, Atsuya Ikeda, Yuji Kamikubo, Tadafumi Hashimoto, Takeshi Iwatsubo, Takashi Sakurai, Takashi Uehara, Nobumasa Takasugi

bioRxiv 2021.07.30.454423; doi: https://doi.org/10.1101/2021.07.30.454423

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