PERK inhibition blocks metastasis initiation by limiting UPR-dependent survival of dormant disseminated cancer cells

Veronica Calvo; Wei Zheng; Kirk A. Staschke; Julie Cheung; Ana Rita Nobre; Eduardo F. Farias; Ari Nowacek; Mark Mulvihill; Alan C. Rigby; Julio A. Aguirre-Ghiso

doi:10.1101/2021.07.30.454473

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PERK inhibition blocks metastasis initiation by limiting UPR-dependent survival of dormant disseminated cancer cells

Veronica Calvo, View ORCID ProfileWei Zheng, Kirk A. Staschke, Julie Cheung, Ana Rita Nobre, Eduardo F. Farias, Ari Nowacek, Mark Mulvihill, Alan C. Rigby, Julio A. Aguirre-Ghiso

doi: https://doi.org/10.1101/2021.07.30.454473

Veronica Calvo

1Division of Hematology and Oncology, Department of Medicine and Department of Otolaryngology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA

3HiberCell, Inc, 619 West 54th Street, 8th Floor, New York, NY USA

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Wei Zheng

1Division of Hematology and Oncology, Department of Medicine and Department of Otolaryngology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA

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ORCID record for Wei Zheng

Kirk A. Staschke

2Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, IN, USA

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Julie Cheung

1Division of Hematology and Oncology, Department of Medicine and Department of Otolaryngology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA

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Ana Rita Nobre

1Division of Hematology and Oncology, Department of Medicine and Department of Otolaryngology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA

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Eduardo F. Farias

1Division of Hematology and Oncology, Department of Medicine and Department of Otolaryngology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA

3HiberCell, Inc, 619 West 54th Street, 8th Floor, New York, NY USA

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Ari Nowacek

3HiberCell, Inc, 619 West 54th Street, 8th Floor, New York, NY USA

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Mark Mulvihill

3HiberCell, Inc, 619 West 54th Street, 8th Floor, New York, NY USA

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Alan C. Rigby

3HiberCell, Inc, 619 West 54th Street, 8th Floor, New York, NY USA

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Julio A. Aguirre-Ghiso

1Division of Hematology and Oncology, Department of Medicine and Department of Otolaryngology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA

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For correspondence: julio.aguirre-ghiso@mssm.edu

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Posted July 30, 2021.

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PERK inhibition blocks metastasis initiation by limiting UPR-dependent survival of dormant disseminated cancer cells

Veronica Calvo, Wei Zheng, Kirk A. Staschke, Julie Cheung, Ana Rita Nobre, Eduardo F. Farias, Ari Nowacek, Mark Mulvihill, Alan C. Rigby, Julio A. Aguirre-Ghiso

bioRxiv 2021.07.30.454473; doi: https://doi.org/10.1101/2021.07.30.454473

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PERK inhibition blocks metastasis initiation by limiting UPR-dependent survival of dormant disseminated cancer cells

Veronica Calvo, Wei Zheng, Kirk A. Staschke, Julie Cheung, Ana Rita Nobre, Eduardo F. Farias, Ari Nowacek, Mark Mulvihill, Alan C. Rigby, Julio A. Aguirre-Ghiso

bioRxiv 2021.07.30.454473; doi: https://doi.org/10.1101/2021.07.30.454473

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