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Genome-wide DNA methylation and multi-omics study of human chondrocyte ontogeny and an epigenetic clock analysis of adult chondrocytes

Arijita Sarkar, Siyoung Lee, Ruzanna Shkhyan, Nancy Q. Liu, Ben Van Handel, Jenny Magallanes, Youngjoo Lee, Litao Tao, Neil Segil, Jason Ernst, Steve Horvath, Denis Evseenko
doi: https://doi.org/10.1101/2021.08.02.454544
Arijita Sarkar
1Department of Orthopaedic Surgery, Keck School of Medicine of USC, University of Southern California (USC), Los Angeles, CA, 90033, USA
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Siyoung Lee
1Department of Orthopaedic Surgery, Keck School of Medicine of USC, University of Southern California (USC), Los Angeles, CA, 90033, USA
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Ruzanna Shkhyan
1Department of Orthopaedic Surgery, Keck School of Medicine of USC, University of Southern California (USC), Los Angeles, CA, 90033, USA
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Nancy Q. Liu
1Department of Orthopaedic Surgery, Keck School of Medicine of USC, University of Southern California (USC), Los Angeles, CA, 90033, USA
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Ben Van Handel
1Department of Orthopaedic Surgery, Keck School of Medicine of USC, University of Southern California (USC), Los Angeles, CA, 90033, USA
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Jenny Magallanes
1Department of Orthopaedic Surgery, Keck School of Medicine of USC, University of Southern California (USC), Los Angeles, CA, 90033, USA
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Youngjoo Lee
1Department of Orthopaedic Surgery, Keck School of Medicine of USC, University of Southern California (USC), Los Angeles, CA, 90033, USA
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Litao Tao
2Department of Stem Cell and Regenerative Medicine, University of Southern California, Los Angeles, CA, 90033, USA
3Eli and Edythe Broad Center, University of Southern California, Los Angeles, CA, 90033, USA
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Neil Segil
2Department of Stem Cell and Regenerative Medicine, University of Southern California, Los Angeles, CA, 90033, USA
3Eli and Edythe Broad Center, University of Southern California, Los Angeles, CA, 90033, USA
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Jason Ernst
4Department of Biological Chemistry, UCLA, Los Angeles, CA 90095, USA
5Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA, Los Angeles, CA 90095, USA
6Computer Science Department, University of California, Los Angeles, CA 90095, USA
7Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA 90095, USA
8Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA
9Department of Computational Medicine, University of California, Los Angeles, CA 90095, USA
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Steve Horvath
10Department of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, CA 90095, USA
11Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
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  • For correspondence: evseenko@usc.edu
Denis Evseenko
1Department of Orthopaedic Surgery, Keck School of Medicine of USC, University of Southern California (USC), Los Angeles, CA, 90033, USA
2Department of Stem Cell and Regenerative Medicine, University of Southern California, Los Angeles, CA, 90033, USA
3Eli and Edythe Broad Center, University of Southern California, Los Angeles, CA, 90033, USA
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  • For correspondence: evseenko@usc.edu
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Article Information

doi 
https://doi.org/10.1101/2021.08.02.454544
History 
  • August 2, 2021.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Arijita Sarkar1,
  2. Siyoung Lee1,
  3. Ruzanna Shkhyan1,
  4. Nancy Q. Liu1,
  5. Ben Van Handel1,
  6. Jenny Magallanes1,
  7. Youngjoo Lee1,
  8. Litao Tao2,3,
  9. Neil Segil2,3,
  10. Jason Ernst4,5,6,7,8,9,
  11. Steve Horvath10,11,# and
  12. Denis Evseenko1,2,3,#
  1. 1Department of Orthopaedic Surgery, Keck School of Medicine of USC, University of Southern California (USC), Los Angeles, CA, 90033, USA
  2. 2Department of Stem Cell and Regenerative Medicine, University of Southern California, Los Angeles, CA, 90033, USA
  3. 3Eli and Edythe Broad Center, University of Southern California, Los Angeles, CA, 90033, USA
  4. 4Department of Biological Chemistry, UCLA, Los Angeles, CA 90095, USA
  5. 5Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA, Los Angeles, CA 90095, USA
  6. 6Computer Science Department, University of California, Los Angeles, CA 90095, USA
  7. 7Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA 90095, USA
  8. 8Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA
  9. 9Department of Computational Medicine, University of California, Los Angeles, CA 90095, USA
  10. 10Department of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, CA 90095, USA
  11. 11Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
  1. ↵#Corresponding authors evseenko{at}usc.edu
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Genome-wide DNA methylation and multi-omics study of human chondrocyte ontogeny and an epigenetic clock analysis of adult chondrocytes
Arijita Sarkar, Siyoung Lee, Ruzanna Shkhyan, Nancy Q. Liu, Ben Van Handel, Jenny Magallanes, Youngjoo Lee, Litao Tao, Neil Segil, Jason Ernst, Steve Horvath, Denis Evseenko
bioRxiv 2021.08.02.454544; doi: https://doi.org/10.1101/2021.08.02.454544
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Genome-wide DNA methylation and multi-omics study of human chondrocyte ontogeny and an epigenetic clock analysis of adult chondrocytes
Arijita Sarkar, Siyoung Lee, Ruzanna Shkhyan, Nancy Q. Liu, Ben Van Handel, Jenny Magallanes, Youngjoo Lee, Litao Tao, Neil Segil, Jason Ernst, Steve Horvath, Denis Evseenko
bioRxiv 2021.08.02.454544; doi: https://doi.org/10.1101/2021.08.02.454544

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