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Rapid encoding of task regularities in the human hippocampus guides sensorimotor timing

View ORCID ProfileIgnacio Polti, View ORCID ProfileMatthias Nau, View ORCID ProfileRaphael Kaplan, View ORCID ProfileVirginie van Wassenhove, View ORCID ProfileChristian F. Doeller
doi: https://doi.org/10.1101/2021.08.03.454928
Ignacio Polti
1Kavli Institute for Systems Neuroscience, Centre for Neural Computation, The Egil and Pauline Braathen and Fred Kavli Centre for Cortical Microcircuits, Jebsen Centre for Alzheimer’s Disease, Norwegian University of Science and Technology, Trondheim, Norway
2Max-Planck-Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
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  • For correspondence: ignacio.polti@ntnu.no matthias.nau@nih.gov
Matthias Nau
1Kavli Institute for Systems Neuroscience, Centre for Neural Computation, The Egil and Pauline Braathen and Fred Kavli Centre for Cortical Microcircuits, Jebsen Centre for Alzheimer’s Disease, Norwegian University of Science and Technology, Trondheim, Norway
2Max-Planck-Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
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  • For correspondence: ignacio.polti@ntnu.no matthias.nau@nih.gov
Raphael Kaplan
1Kavli Institute for Systems Neuroscience, Centre for Neural Computation, The Egil and Pauline Braathen and Fred Kavli Centre for Cortical Microcircuits, Jebsen Centre for Alzheimer’s Disease, Norwegian University of Science and Technology, Trondheim, Norway
3Department of Basic Psychology, Clinical Psychology, and Psychobiology, Universitat Jaume I, Castellón de la Plana, Spain
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Virginie van Wassenhove
4CEA DRF/Joliot, NeuroSpin; INSERM, Cognitive Neuroimaging Unit; CNRS, Université Paris-Saclay, Gif-Sur-Yvette, France
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Christian F. Doeller
1Kavli Institute for Systems Neuroscience, Centre for Neural Computation, The Egil and Pauline Braathen and Fred Kavli Centre for Cortical Microcircuits, Jebsen Centre for Alzheimer’s Disease, Norwegian University of Science and Technology, Trondheim, Norway
2Max-Planck-Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
5Institute of Psychology, Leipzig University, Leipzig, Germany
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Abstract

The brain encodes the statistical regularities of the environment in a task-specific yet flexible and generalizable format. Here, we seek to understand this process by converging two parallel lines of research, one centered on sensorimotor timing, and the other on cognitive mapping in the hippocampal system. By combining functional magnetic resonance imaging (fMRI) with a fast-paced time-to-contact (TTC) estimation task, we found that the hippocampus signaled behavioral feedback and sensorimotor learning in each trial along with reward-processing regions. Critically, these hippocampal learning signals generalized across tested intervals and accounted for the trial-wise regression-to-the-mean biases in TTC estimation. This suggests that the capacity of the hippocampus to generalize supports the rapid encoding of temporal context even on short time scales in a behavior-dependent manner. Our results emphasize the central role of the hippocampus in statistical learning, positioning it at the core of a brain-wide network balancing task specificity vs. generalization for flexible behavior.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • ↵* Shared-first authors

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted November 03, 2021.
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Rapid encoding of task regularities in the human hippocampus guides sensorimotor timing
Ignacio Polti, Matthias Nau, Raphael Kaplan, Virginie van Wassenhove, Christian F. Doeller
bioRxiv 2021.08.03.454928; doi: https://doi.org/10.1101/2021.08.03.454928
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Rapid encoding of task regularities in the human hippocampus guides sensorimotor timing
Ignacio Polti, Matthias Nau, Raphael Kaplan, Virginie van Wassenhove, Christian F. Doeller
bioRxiv 2021.08.03.454928; doi: https://doi.org/10.1101/2021.08.03.454928

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