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The emergence of highly fit SARS-CoV-2 variants accelerated by epistasis and caused by recombination

Michael R. Garvin, Erica T. Prates, Jonathon Romero, Ashley Cliff, Joao Gabriel Felipe Machado Gazolla, Monica Pickholz, Mirko Pavicic, View ORCID ProfileDaniel Jacobson
doi: https://doi.org/10.1101/2021.08.03.454981
Michael R. Garvin
1Oak Ridge National Laboratory, Computational Systems Biology, Biosciences, Oak Ridge, TN
2National Virtual Biotechnology Laboratory, US Department of Energy;
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  • For correspondence: garvinmr@ornl.gov jacobsonda@ornl.gov
Erica T. Prates
1Oak Ridge National Laboratory, Computational Systems Biology, Biosciences, Oak Ridge, TN
2National Virtual Biotechnology Laboratory, US Department of Energy;
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Jonathon Romero
3The Bredesen Center for Interdisciplinary Research and Graduate Education, University of Tennessee Knoxville, Knoxville, TN
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Ashley Cliff
3The Bredesen Center for Interdisciplinary Research and Graduate Education, University of Tennessee Knoxville, Knoxville, TN
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Joao Gabriel Felipe Machado Gazolla
1Oak Ridge National Laboratory, Computational Systems Biology, Biosciences, Oak Ridge, TN
2National Virtual Biotechnology Laboratory, US Department of Energy;
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Monica Pickholz
4Departamento de Física, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
5Instituto de Física de Buenos Aires (IFIBA), CONICET-Universidad de Buenos Aires, Buenos Aires, Argentina
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Mirko Pavicic
1Oak Ridge National Laboratory, Computational Systems Biology, Biosciences, Oak Ridge, TN
2National Virtual Biotechnology Laboratory, US Department of Energy;
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Daniel Jacobson
1Oak Ridge National Laboratory, Computational Systems Biology, Biosciences, Oak Ridge, TN
2National Virtual Biotechnology Laboratory, US Department of Energy;
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  • ORCID record for Daniel Jacobson
  • For correspondence: garvinmr@ornl.gov jacobsonda@ornl.gov
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Article Information

doi 
https://doi.org/10.1101/2021.08.03.454981
History 
  • August 24, 2021.

Article Versions

  • Version 1 (August 8, 2021 - 16:01).
  • Version 2 (August 10, 2021 - 07:23).
  • You are currently viewing Version 3 of this article (August 24, 2021 - 11:03).
  • View Version 4, the most recent version of this article.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

Author Information

  1. Michael R. Garvin1,2,*,+,
  2. Erica T. Prates1,2,+,
  3. Jonathon Romero3,
  4. Ashley Cliff3,
  5. Joao Gabriel Felipe Machado Gazolla1,2,
  6. Monica Pickholz4,5,
  7. Mirko Pavicic1,2 and
  8. Daniel Jacobson1,2,*
  1. 1Oak Ridge National Laboratory, Computational Systems Biology, Biosciences, Oak Ridge, TN
  2. 2National Virtual Biotechnology Laboratory, US Department of Energy;
  3. 3The Bredesen Center for Interdisciplinary Research and Graduate Education, University of Tennessee Knoxville, Knoxville, TN
  4. 4Departamento de Física, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
  5. 5Instituto de Física de Buenos Aires (IFIBA), CONICET-Universidad de Buenos Aires, Buenos Aires, Argentina
  1. ↵*Correspondence: garvinmr{at}ornl.gov, jacobsonda{at}ornl.gov
  1. ↵+ Contributed equally

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Posted August 24, 2021.
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The emergence of highly fit SARS-CoV-2 variants accelerated by epistasis and caused by recombination
Michael R. Garvin, Erica T. Prates, Jonathon Romero, Ashley Cliff, Joao Gabriel Felipe Machado Gazolla, Monica Pickholz, Mirko Pavicic, Daniel Jacobson
bioRxiv 2021.08.03.454981; doi: https://doi.org/10.1101/2021.08.03.454981
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The emergence of highly fit SARS-CoV-2 variants accelerated by epistasis and caused by recombination
Michael R. Garvin, Erica T. Prates, Jonathon Romero, Ashley Cliff, Joao Gabriel Felipe Machado Gazolla, Monica Pickholz, Mirko Pavicic, Daniel Jacobson
bioRxiv 2021.08.03.454981; doi: https://doi.org/10.1101/2021.08.03.454981

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