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Opposing roles of p38α-mediated phosphorylation and arginine methylation in driving TDP-43 proteinopathy
Mari Aikio, Heike J. Wobst, Hana M. Odeh, Bo Lim Lee, Bradley Class, Thomas A. Ollerhead, Korrie L. Mack, Alice F. Ford, Edward M. Barbieri, View ORCID ProfileRyan R. Cupo, Lauren E. Drake, Nicholas Castello, Ashmita Baral, John Dunlop, Aaron D. Gitler, Ashkan Javaherian, Steven Finkbeiner, Dean G. Brown, Stephen J. Moss, Nicholas J. Brandon, View ORCID ProfileJames Shorter
doi: https://doi.org/10.1101/2021.08.04.455154
Mari Aikio
1AstraZeneca-Tufts Laboratory for Basic and Translational Neuroscience, Tufts University, Boston, MA, U.S.A.
Heike J. Wobst
2Neuroscience, BioPharmaceuticals R&D, AstraZeneca, Boston, MA, U.S.A.
Hana M. Odeh
3Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, U.S.A.
Bo Lim Lee
3Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, U.S.A.
Bradley Class
2Neuroscience, BioPharmaceuticals R&D, AstraZeneca, Boston, MA, U.S.A.
Thomas A. Ollerhead
1AstraZeneca-Tufts Laboratory for Basic and Translational Neuroscience, Tufts University, Boston, MA, U.S.A.
Korrie L. Mack
3Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, U.S.A.
4Biochemistry and Molecular Biophysics Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, U.S.A.
Alice F. Ford
3Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, U.S.A.
5Neuroscience Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, U.S.A.
Edward M. Barbieri
3Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, U.S.A.
Ryan R. Cupo
3Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, U.S.A.
6Pharmacology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, U.S.A.
Lauren E. Drake
3Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, U.S.A.
Nicholas Castello
7Center for Systems and Therapeutics, Taube/Koret Center for Neurodegenerative Disease Research, Gladstone Institutes, San Francisco, CA, U.S.A.
Ashmita Baral
7Center for Systems and Therapeutics, Taube/Koret Center for Neurodegenerative Disease Research, Gladstone Institutes, San Francisco, CA, U.S.A.
John Dunlop
2Neuroscience, BioPharmaceuticals R&D, AstraZeneca, Boston, MA, U.S.A.
Aaron D. Gitler
8Department of Genetics, Stanford University School of Medicine, Stanford, CA, U.S.A.
Ashkan Javaherian
7Center for Systems and Therapeutics, Taube/Koret Center for Neurodegenerative Disease Research, Gladstone Institutes, San Francisco, CA, U.S.A.
Steven Finkbeiner
7Center for Systems and Therapeutics, Taube/Koret Center for Neurodegenerative Disease Research, Gladstone Institutes, San Francisco, CA, U.S.A.
9Deparments of Neurology and Physiology, University of California, San Francisco, CA, U.S.A.
Dean G. Brown
10Hit Discovery, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Boston, MA, U.S.A.
Stephen J. Moss
1AstraZeneca-Tufts Laboratory for Basic and Translational Neuroscience, Tufts University, Boston, MA, U.S.A.
Nicholas J. Brandon
1AstraZeneca-Tufts Laboratory for Basic and Translational Neuroscience, Tufts University, Boston, MA, U.S.A.
2Neuroscience, BioPharmaceuticals R&D, AstraZeneca, Boston, MA, U.S.A.
James Shorter
3Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, U.S.A.
4Biochemistry and Molecular Biophysics Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, U.S.A.
5Neuroscience Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, U.S.A.
6Pharmacology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, U.S.A.
Article usage
Posted August 04, 2021.
Opposing roles of p38α-mediated phosphorylation and arginine methylation in driving TDP-43 proteinopathy
Mari Aikio, Heike J. Wobst, Hana M. Odeh, Bo Lim Lee, Bradley Class, Thomas A. Ollerhead, Korrie L. Mack, Alice F. Ford, Edward M. Barbieri, Ryan R. Cupo, Lauren E. Drake, Nicholas Castello, Ashmita Baral, John Dunlop, Aaron D. Gitler, Ashkan Javaherian, Steven Finkbeiner, Dean G. Brown, Stephen J. Moss, Nicholas J. Brandon, James Shorter
bioRxiv 2021.08.04.455154; doi: https://doi.org/10.1101/2021.08.04.455154
Opposing roles of p38α-mediated phosphorylation and arginine methylation in driving TDP-43 proteinopathy
Mari Aikio, Heike J. Wobst, Hana M. Odeh, Bo Lim Lee, Bradley Class, Thomas A. Ollerhead, Korrie L. Mack, Alice F. Ford, Edward M. Barbieri, Ryan R. Cupo, Lauren E. Drake, Nicholas Castello, Ashmita Baral, John Dunlop, Aaron D. Gitler, Ashkan Javaherian, Steven Finkbeiner, Dean G. Brown, Stephen J. Moss, Nicholas J. Brandon, James Shorter
bioRxiv 2021.08.04.455154; doi: https://doi.org/10.1101/2021.08.04.455154
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