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SARS-CoV-2 variants of concern have acquired mutations associated with an increased spike cleavage
View ORCID ProfileAlba Escalera, View ORCID ProfileAna S. Gonzalez-Reiche, Sadaf Aslam, View ORCID ProfileIgnacio Mena, View ORCID ProfileRebecca L. Pearl, View ORCID ProfileManon Laporte, Andrea Fossati, View ORCID ProfileRaveen Rathnasinghe, View ORCID ProfileHala Alshammary, View ORCID ProfileAdriana van de Guchte, View ORCID ProfileMehdi Bouhaddou, View ORCID ProfileThomas Kehrer, Lorena Zuliani-Alvarez, David A. Meekins, View ORCID ProfileVelmurugan Balaraman, Chester McDowell, Jürgen A. Richt, View ORCID ProfileGoran Bajic, View ORCID ProfileEmilia Mia Sordillo, View ORCID ProfileNevan Krogan, View ORCID ProfileViviana Simon, View ORCID ProfileRandy A. Albrecht, View ORCID ProfileHarm van Bakel, View ORCID ProfileAdolfo Garcia-Sastre, View ORCID ProfileTeresa Aydillo
doi: https://doi.org/10.1101/2021.08.05.455290
Alba Escalera
1Department of Microbiology, Icahn School of Medicine at Mount Sinai; New York, NY, USA
2Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai; New York, NY, USA
3Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai; New York, NY, USA
Ana S. Gonzalez-Reiche
4Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai; New York, NY, USA
Sadaf Aslam
1Department of Microbiology, Icahn School of Medicine at Mount Sinai; New York, NY, USA
2Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai; New York, NY, USA
Ignacio Mena
1Department of Microbiology, Icahn School of Medicine at Mount Sinai; New York, NY, USA
2Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai; New York, NY, USA
Rebecca L. Pearl
1Department of Microbiology, Icahn School of Medicine at Mount Sinai; New York, NY, USA
2Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai; New York, NY, USA
Manon Laporte
1Department of Microbiology, Icahn School of Medicine at Mount Sinai; New York, NY, USA
2Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai; New York, NY, USA
Andrea Fossati
5Quantitative Biosciences Institute (QBI), University of California San Francisco; San Francisco, CA, USA
6QBI COVID-19 Research Group (QCRG); San Francisco, CA, USA
7J. David Gladstone Institutes; San Francisco, CA, USA
8Department of Cellular and Molecular Pharmacology, University of California San Francisco; San Francisco, CA, USA
Raveen Rathnasinghe
1Department of Microbiology, Icahn School of Medicine at Mount Sinai; New York, NY, USA
2Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai; New York, NY, USA
3Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai; New York, NY, USA
Hala Alshammary
1Department of Microbiology, Icahn School of Medicine at Mount Sinai; New York, NY, USA
Adriana van de Guchte
4Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai; New York, NY, USA
Mehdi Bouhaddou
5Quantitative Biosciences Institute (QBI), University of California San Francisco; San Francisco, CA, USA
6QBI COVID-19 Research Group (QCRG); San Francisco, CA, USA
7J. David Gladstone Institutes; San Francisco, CA, USA
8Department of Cellular and Molecular Pharmacology, University of California San Francisco; San Francisco, CA, USA
Thomas Kehrer
1Department of Microbiology, Icahn School of Medicine at Mount Sinai; New York, NY, USA
2Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai; New York, NY, USA
3Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai; New York, NY, USA
Lorena Zuliani-Alvarez
5Quantitative Biosciences Institute (QBI), University of California San Francisco; San Francisco, CA, USA
6QBI COVID-19 Research Group (QCRG); San Francisco, CA, USA
7J. David Gladstone Institutes; San Francisco, CA, USA
8Department of Cellular and Molecular Pharmacology, University of California San Francisco; San Francisco, CA, USA
David A. Meekins
9Department of Diagnostic Medicine/Pathobiology and Center of Excellence for Emerging and Zoonotic Animal Diseases, College of Veterinary Medicine; Kansas State University, Manhattan, KS, USA
Velmurugan Balaraman
9Department of Diagnostic Medicine/Pathobiology and Center of Excellence for Emerging and Zoonotic Animal Diseases, College of Veterinary Medicine; Kansas State University, Manhattan, KS, USA
Chester McDowell
9Department of Diagnostic Medicine/Pathobiology and Center of Excellence for Emerging and Zoonotic Animal Diseases, College of Veterinary Medicine; Kansas State University, Manhattan, KS, USA
Jürgen A. Richt
9Department of Diagnostic Medicine/Pathobiology and Center of Excellence for Emerging and Zoonotic Animal Diseases, College of Veterinary Medicine; Kansas State University, Manhattan, KS, USA
Goran Bajic
1Department of Microbiology, Icahn School of Medicine at Mount Sinai; New York, NY, USA
Emilia Mia Sordillo
10Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai; New York, NY, USA
Nevan Krogan
1Department of Microbiology, Icahn School of Medicine at Mount Sinai; New York, NY, USA
5Quantitative Biosciences Institute (QBI), University of California San Francisco; San Francisco, CA, USA
6QBI COVID-19 Research Group (QCRG); San Francisco, CA, USA
7J. David Gladstone Institutes; San Francisco, CA, USA
8Department of Cellular and Molecular Pharmacology, University of California San Francisco; San Francisco, CA, USA
Viviana Simon
1Department of Microbiology, Icahn School of Medicine at Mount Sinai; New York, NY, USA
2Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai; New York, NY, USA
10Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai; New York, NY, USA
11Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai; New York, NY, USA
Randy A. Albrecht
1Department of Microbiology, Icahn School of Medicine at Mount Sinai; New York, NY, USA
2Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai; New York, NY, USA
Harm van Bakel
4Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai; New York, NY, USA
12Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai; New York, NY, USA
Adolfo Garcia-Sastre
1Department of Microbiology, Icahn School of Medicine at Mount Sinai; New York, NY, USA
2Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai; New York, NY, USA
10Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai; New York, NY, USA
11Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai; New York, NY, USA
13The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai; New York, NY, USA
Teresa Aydillo
1Department of Microbiology, Icahn School of Medicine at Mount Sinai; New York, NY, USA
2Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai; New York, NY, USA
Posted August 05, 2021.
SARS-CoV-2 variants of concern have acquired mutations associated with an increased spike cleavage
Alba Escalera, Ana S. Gonzalez-Reiche, Sadaf Aslam, Ignacio Mena, Rebecca L. Pearl, Manon Laporte, Andrea Fossati, Raveen Rathnasinghe, Hala Alshammary, Adriana van de Guchte, Mehdi Bouhaddou, Thomas Kehrer, Lorena Zuliani-Alvarez, David A. Meekins, Velmurugan Balaraman, Chester McDowell, Jürgen A. Richt, Goran Bajic, Emilia Mia Sordillo, Nevan Krogan, Viviana Simon, Randy A. Albrecht, Harm van Bakel, Adolfo Garcia-Sastre, Teresa Aydillo
bioRxiv 2021.08.05.455290; doi: https://doi.org/10.1101/2021.08.05.455290
SARS-CoV-2 variants of concern have acquired mutations associated with an increased spike cleavage
Alba Escalera, Ana S. Gonzalez-Reiche, Sadaf Aslam, Ignacio Mena, Rebecca L. Pearl, Manon Laporte, Andrea Fossati, Raveen Rathnasinghe, Hala Alshammary, Adriana van de Guchte, Mehdi Bouhaddou, Thomas Kehrer, Lorena Zuliani-Alvarez, David A. Meekins, Velmurugan Balaraman, Chester McDowell, Jürgen A. Richt, Goran Bajic, Emilia Mia Sordillo, Nevan Krogan, Viviana Simon, Randy A. Albrecht, Harm van Bakel, Adolfo Garcia-Sastre, Teresa Aydillo
bioRxiv 2021.08.05.455290; doi: https://doi.org/10.1101/2021.08.05.455290
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