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A LINCS microenvironment perturbation resource for integrative assessment of ligand-mediated molecular and phenotypic responses
Sean M. Gross, Mark A. Dane, Rebecca L. Smith, Kaylyn Devlin, Ian McLean, Daniel Derrick, Caitlin Mills, Kartik Subramanian, Alexandra B. London, Denis Torre, Cemal Erdem, Nicholas Lyons, Ted Natoli, Sarah Pessa, Xiaodong Lu, James Mullahoo, Jonathan Li, Miriam Adam, Brook Wassie, Moqing Liu, David Kilburn, Tiera A. Liby, Elmar Bucher, Crystal Sanchez-Aguila, Kenneth Daily, Larsson Omberg, Yunguan Wang, Connor Jacobson, Clarence Yapp, Mirra Chung, Dusica Vidovic, Yiling Lu, Stephan Schurer, Albert Lee, Ajay Pillai, Aravind Subramanian, Malvina Papanastasiou, Ernest Fraenkel, Heidi S. Feiler, Gordon B. Mills, Jake Jaffe, Avi Ma’ayan, Marc R. Birtwistle, Peter K. Sorger, James E. Korkola, Joe W. Gray, Laura M. Heiser
doi: https://doi.org/10.1101/2021.08.06.455429
Sean M. Gross
1Department of Biomedical Engineering, OHSU, Portland, OR, USA
Mark A. Dane
1Department of Biomedical Engineering, OHSU, Portland, OR, USA
Rebecca L. Smith
1Department of Biomedical Engineering, OHSU, Portland, OR, USA
Kaylyn Devlin
1Department of Biomedical Engineering, OHSU, Portland, OR, USA
Ian McLean
1Department of Biomedical Engineering, OHSU, Portland, OR, USA
Daniel Derrick
1Department of Biomedical Engineering, OHSU, Portland, OR, USA
Caitlin Mills
2Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Program in Therapeutic Science, Harvard Medical School, Boston, MA, USA
Kartik Subramanian
2Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Program in Therapeutic Science, Harvard Medical School, Boston, MA, USA
Alexandra B. London
3Department of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Denis Torre
3Department of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Cemal Erdem
4Department of Chemical and Biomolecular Engineering, Clemson University, Clemson, SC, USA
Nicholas Lyons
5Broad Institute of MIT and Harvard, Cambridge, MA, USA
Ted Natoli
5Broad Institute of MIT and Harvard, Cambridge, MA, USA
Sarah Pessa
5Broad Institute of MIT and Harvard, Cambridge, MA, USA
Xiaodong Lu
5Broad Institute of MIT and Harvard, Cambridge, MA, USA
James Mullahoo
5Broad Institute of MIT and Harvard, Cambridge, MA, USA
Jonathan Li
6Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA
Miriam Adam
6Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA
Brook Wassie
6Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA
Moqing Liu
1Department of Biomedical Engineering, OHSU, Portland, OR, USA
David Kilburn
1Department of Biomedical Engineering, OHSU, Portland, OR, USA
Tiera A. Liby
1Department of Biomedical Engineering, OHSU, Portland, OR, USA
Elmar Bucher
1Department of Biomedical Engineering, OHSU, Portland, OR, USA
Crystal Sanchez-Aguila
1Department of Biomedical Engineering, OHSU, Portland, OR, USA
Kenneth Daily
7Sage Bionetworks, Seattle, WA, USA
Larsson Omberg
7Sage Bionetworks, Seattle, WA, USA
Yunguan Wang
2Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Program in Therapeutic Science, Harvard Medical School, Boston, MA, USA
Connor Jacobson
2Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Program in Therapeutic Science, Harvard Medical School, Boston, MA, USA
Clarence Yapp
2Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Program in Therapeutic Science, Harvard Medical School, Boston, MA, USA
Mirra Chung
2Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Program in Therapeutic Science, Harvard Medical School, Boston, MA, USA
Dusica Vidovic
8Sylvester Comprehensive Cancer Center, University of Miami, FL 33136, USA
9Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
10Institute for Data Science & Computing, University of Miami, FL 33136, USA
Yiling Lu
11Department of Genomic Medicine, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Stephan Schurer
8Sylvester Comprehensive Cancer Center, University of Miami, FL 33136, USA
9Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
10Institute for Data Science & Computing, University of Miami, FL 33136, USA
Albert Lee
12Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, USA
Ajay Pillai
13Human Genome Research Institute, National Institutes of Health, Bethesda, USA
Aravind Subramanian
5Broad Institute of MIT and Harvard, Cambridge, MA, USA
Malvina Papanastasiou
5Broad Institute of MIT and Harvard, Cambridge, MA, USA
Ernest Fraenkel
6Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA
Heidi S. Feiler
1Department of Biomedical Engineering, OHSU, Portland, OR, USA
Gordon B. Mills
14Department of Cancer, Developmental and Cell Biology, OHSU, Portland, OR, USA
15Knight Cancer Institute, OHSU, Portland, OR, USA
Jake Jaffe
5Broad Institute of MIT and Harvard, Cambridge, MA, USA
Avi Ma’ayan
3Department of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Marc R. Birtwistle
4Department of Chemical and Biomolecular Engineering, Clemson University, Clemson, SC, USA
Peter K. Sorger
2Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Program in Therapeutic Science, Harvard Medical School, Boston, MA, USA
James E. Korkola
1Department of Biomedical Engineering, OHSU, Portland, OR, USA
15Knight Cancer Institute, OHSU, Portland, OR, USA
Joe W. Gray
1Department of Biomedical Engineering, OHSU, Portland, OR, USA
15Knight Cancer Institute, OHSU, Portland, OR, USA
Laura M. Heiser
1Department of Biomedical Engineering, OHSU, Portland, OR, USA
15Knight Cancer Institute, OHSU, Portland, OR, USA
Article usage
Posted August 09, 2021.
A LINCS microenvironment perturbation resource for integrative assessment of ligand-mediated molecular and phenotypic responses
Sean M. Gross, Mark A. Dane, Rebecca L. Smith, Kaylyn Devlin, Ian McLean, Daniel Derrick, Caitlin Mills, Kartik Subramanian, Alexandra B. London, Denis Torre, Cemal Erdem, Nicholas Lyons, Ted Natoli, Sarah Pessa, Xiaodong Lu, James Mullahoo, Jonathan Li, Miriam Adam, Brook Wassie, Moqing Liu, David Kilburn, Tiera A. Liby, Elmar Bucher, Crystal Sanchez-Aguila, Kenneth Daily, Larsson Omberg, Yunguan Wang, Connor Jacobson, Clarence Yapp, Mirra Chung, Dusica Vidovic, Yiling Lu, Stephan Schurer, Albert Lee, Ajay Pillai, Aravind Subramanian, Malvina Papanastasiou, Ernest Fraenkel, Heidi S. Feiler, Gordon B. Mills, Jake Jaffe, Avi Ma’ayan, Marc R. Birtwistle, Peter K. Sorger, James E. Korkola, Joe W. Gray, Laura M. Heiser
bioRxiv 2021.08.06.455429; doi: https://doi.org/10.1101/2021.08.06.455429
A LINCS microenvironment perturbation resource for integrative assessment of ligand-mediated molecular and phenotypic responses
Sean M. Gross, Mark A. Dane, Rebecca L. Smith, Kaylyn Devlin, Ian McLean, Daniel Derrick, Caitlin Mills, Kartik Subramanian, Alexandra B. London, Denis Torre, Cemal Erdem, Nicholas Lyons, Ted Natoli, Sarah Pessa, Xiaodong Lu, James Mullahoo, Jonathan Li, Miriam Adam, Brook Wassie, Moqing Liu, David Kilburn, Tiera A. Liby, Elmar Bucher, Crystal Sanchez-Aguila, Kenneth Daily, Larsson Omberg, Yunguan Wang, Connor Jacobson, Clarence Yapp, Mirra Chung, Dusica Vidovic, Yiling Lu, Stephan Schurer, Albert Lee, Ajay Pillai, Aravind Subramanian, Malvina Papanastasiou, Ernest Fraenkel, Heidi S. Feiler, Gordon B. Mills, Jake Jaffe, Avi Ma’ayan, Marc R. Birtwistle, Peter K. Sorger, James E. Korkola, Joe W. Gray, Laura M. Heiser
bioRxiv 2021.08.06.455429; doi: https://doi.org/10.1101/2021.08.06.455429
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