Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Blocking cell fusion inhibits age-induced polyploidy and maintains epithelial organization in Drosophila

Ari S. Dehn, Navdeep Gogna, Patsy M. Nishina, View ORCID ProfileVicki P. Losick
doi: https://doi.org/10.1101/2021.08.09.455651
Ari S. Dehn
1Boston College, 140 Commonwealth Ave, Chestnut Hill, MA 02467
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Navdeep Gogna
2The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Patsy M. Nishina
2The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Vicki P. Losick
1Boston College, 140 Commonwealth Ave, Chestnut Hill, MA 02467
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Vicki P. Losick
  • For correspondence: vicki.losick@bc.edu
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Supplementary material
  • Preview PDF
Loading

Summary

A characteristic of normal aging and age-related diseases is the remodeling of a tissue’s cellular organization through polyploid cell growth. Polyploidy arises from an increase in nuclear ploidy or the number of nuclei per cell. However, it is not known whether age-induced polyploidy is an adaption to stressors or a precursor to degeneration. Here, we find that the adult fruit fly’s abdominal epithelium becomes polyploid with age through generation of large multinucleated cells that make up more than 40% of the tissue area. The syncytia arise by cell fusion, not endomitosis. Epithelial multinucleation is also a characteristic of macular degeneration, including Ctnna1tvrm5, a mouse model for pattern dystrophy. Similarly, we find that the knockdown of alpha-catenin enhances multinucleation in the fly epithelium. We further show that age-induced polyploidy can be suppressed by inhibiting cell fusion revealing a means to maintain tissue organization in older animals.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
Back to top
PreviousNext
Posted August 09, 2021.
Download PDF

Supplementary Material

Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Blocking cell fusion inhibits age-induced polyploidy and maintains epithelial organization in Drosophila
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Blocking cell fusion inhibits age-induced polyploidy and maintains epithelial organization in Drosophila
Ari S. Dehn, Navdeep Gogna, Patsy M. Nishina, Vicki P. Losick
bioRxiv 2021.08.09.455651; doi: https://doi.org/10.1101/2021.08.09.455651
Digg logo Reddit logo Twitter logo Facebook logo Google logo LinkedIn logo Mendeley logo
Citation Tools
Blocking cell fusion inhibits age-induced polyploidy and maintains epithelial organization in Drosophila
Ari S. Dehn, Navdeep Gogna, Patsy M. Nishina, Vicki P. Losick
bioRxiv 2021.08.09.455651; doi: https://doi.org/10.1101/2021.08.09.455651

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Cell Biology
Subject Areas
All Articles
  • Animal Behavior and Cognition (3589)
  • Biochemistry (7553)
  • Bioengineering (5498)
  • Bioinformatics (20742)
  • Biophysics (10305)
  • Cancer Biology (7962)
  • Cell Biology (11624)
  • Clinical Trials (138)
  • Developmental Biology (6596)
  • Ecology (10175)
  • Epidemiology (2065)
  • Evolutionary Biology (13586)
  • Genetics (9525)
  • Genomics (12824)
  • Immunology (7911)
  • Microbiology (19518)
  • Molecular Biology (7647)
  • Neuroscience (42014)
  • Paleontology (307)
  • Pathology (1254)
  • Pharmacology and Toxicology (2195)
  • Physiology (3260)
  • Plant Biology (7027)
  • Scientific Communication and Education (1294)
  • Synthetic Biology (1948)
  • Systems Biology (5420)
  • Zoology (1113)