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A novel approach to evaluate alpha-synuclein seeding shows a wide heterogeneity in multiple system atrophy

Ivan Martinez-Valbuena, Naomi P. Visanji, Ain Kim, Heather H. C. Lau, Raphaella W. L. So, Sohaila Alshimemeri, Andrew Gao, Michael Seidman, Maria R. Luquin, Joel C. Watts, Anthony E. Lang, View ORCID ProfileGabor G. Kovacs
doi: https://doi.org/10.1101/2021.08.10.455800
Ivan Martinez-Valbuena
1Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada
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Naomi P. Visanji
2Edmond J. Safra Program in Parkinson’s Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, Toronto, Ontario, Canada
3Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
4Krembil Brain Institute, University Health Network, Toronto, Ontario, Canada
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Ain Kim
1Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada
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Heather H. C. Lau
1Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada
5Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada
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Raphaella W. L. So
1Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada
5Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada
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Sohaila Alshimemeri
2Edmond J. Safra Program in Parkinson’s Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, Toronto, Ontario, Canada
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Andrew Gao
3Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
6Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada
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Michael Seidman
3Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
6Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada
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Maria R. Luquin
7Department of Neurology, Clinica Universidad de Navarra, Pamplona, Navarra, Spain
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Joel C. Watts
1Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada
5Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada
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Anthony E. Lang
1Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada
2Edmond J. Safra Program in Parkinson’s Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, Toronto, Ontario, Canada
4Krembil Brain Institute, University Health Network, Toronto, Ontario, Canada
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Gabor G. Kovacs
1Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada
2Edmond J. Safra Program in Parkinson’s Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, Toronto, Ontario, Canada
3Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
4Krembil Brain Institute, University Health Network, Toronto, Ontario, Canada
6Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada
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  • ORCID record for Gabor G. Kovacs
  • For correspondence: gabor.kovacs@uhnresearch.ca
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A novel approach to evaluate alpha-synuclein seeding shows a wide heterogeneity in multiple system atrophy
Ivan Martinez-Valbuena, Naomi P. Visanji, Ain Kim, Heather H. C. Lau, Raphaella W. L. So, Sohaila Alshimemeri, Andrew Gao, Michael Seidman, Maria R. Luquin, Joel C. Watts, Anthony E. Lang, Gabor G. Kovacs
bioRxiv 2021.08.10.455800; doi: https://doi.org/10.1101/2021.08.10.455800
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A novel approach to evaluate alpha-synuclein seeding shows a wide heterogeneity in multiple system atrophy
Ivan Martinez-Valbuena, Naomi P. Visanji, Ain Kim, Heather H. C. Lau, Raphaella W. L. So, Sohaila Alshimemeri, Andrew Gao, Michael Seidman, Maria R. Luquin, Joel C. Watts, Anthony E. Lang, Gabor G. Kovacs
bioRxiv 2021.08.10.455800; doi: https://doi.org/10.1101/2021.08.10.455800

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