Reconstructing transcriptional histories by CRISPR acquisition of retron-based genetic barcodes

Santi Bhattarai-Kline; Elana Lockshin; Max G. Schubert; Jeff Nivala; George Church; Seth L. Shipman

doi:10.1101/2021.08.11.455990

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Reconstructing transcriptional histories by CRISPR acquisition of retron-based genetic barcodes

View ORCID ProfileSanti Bhattarai-Kline, View ORCID ProfileElana Lockshin, View ORCID ProfileMax G. Schubert, View ORCID ProfileJeff Nivala, View ORCID ProfileGeorge Church, View ORCID ProfileSeth L. Shipman

doi: https://doi.org/10.1101/2021.08.11.455990

Santi Bhattarai-Kline

1Gladstone Institute of Data Science and Biotechnology, San Francisco, CA, USA

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Elana Lockshin

2Department of Neurobiology, Duke University Medical Center, Durham, NC, USA

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Max G. Schubert

3Department of Genetics, Harvard Medical School, Boston, MA, USA

4Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA

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Jeff Nivala

5Paul G. Allen School of Computer Science & Engineering, University of Washington, Seattle, WA, USA

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George Church

3Department of Genetics, Harvard Medical School, Boston, MA, USA

4Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA

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Seth L. Shipman

1Gladstone Institute of Data Science and Biotechnology, San Francisco, CA, USA

6Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, USA

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For correspondence: seth.shipman@gladstone.ucsf.edu

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Posted August 12, 2021.

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Reconstructing transcriptional histories by CRISPR acquisition of retron-based genetic barcodes

Santi Bhattarai-Kline, Elana Lockshin, Max G. Schubert, Jeff Nivala, George Church, Seth L. Shipman

bioRxiv 2021.08.11.455990; doi: https://doi.org/10.1101/2021.08.11.455990

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Reconstructing transcriptional histories by CRISPR acquisition of retron-based genetic barcodes

Santi Bhattarai-Kline, Elana Lockshin, Max G. Schubert, Jeff Nivala, George Church, Seth L. Shipman

bioRxiv 2021.08.11.455990; doi: https://doi.org/10.1101/2021.08.11.455990

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