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Overexpression of the SETD2 WW domain inhibits the phosphor-IWS1/SETD2 interaction and the oncogenic AKT/IWS1 RNA splicing program

View ORCID ProfileGeorgios I. Laliotis, Evangelia Chavdoul, Vollter Anastas, Satishkumar Singh, Adam D. Kenney, Samir Acharya, Jacob S. Yount, View ORCID ProfileLalit Sehgal, Philip N. Tsichlis
doi: https://doi.org/10.1101/2021.08.12.454141
Georgios I. Laliotis
1The Ohio State University
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  • For correspondence: glaliot1@jhmi.edu
Evangelia Chavdoul
1The Ohio State University
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Vollter Anastas
2Tufts University School of Medicine
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Satishkumar Singh
1The Ohio State University
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Adam D. Kenney
1The Ohio State University
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Samir Acharya
1The Ohio State University
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Jacob S. Yount
1The Ohio State University
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Lalit Sehgal
3The Ohio state University
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Philip N. Tsichlis
1The Ohio State University
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Abstract

The authors have withdrawn their manuscript. While attempting to reproduce the data on the alternative splicing of exon 2 of U2AF2, they observed that the proposed splicing mechanism could not give rise to a functional U2AF2 protein. In addition, they observed evidence of manipulation in the electropherogram of the splicing junction between exons 1 and 3 and in the primary data on which this electropherogram was based, which were deposited in Mendeley by the first author. These observations raise questions on the integrity of the reported results. In light of this information, the authors have no confidence in the key findings of the paper, and therefore, do not wish it to be cited. If you have any questions, please contact the corresponding author.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • N/A

  • http://doi.org/10.17632/d5kv2dyhc4.1

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.
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Posted August 04, 2022.
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Overexpression of the SETD2 WW domain inhibits the phosphor-IWS1/SETD2 interaction and the oncogenic AKT/IWS1 RNA splicing program
Georgios I. Laliotis, Evangelia Chavdoul, Vollter Anastas, Satishkumar Singh, Adam D. Kenney, Samir Acharya, Jacob S. Yount, Lalit Sehgal, Philip N. Tsichlis
bioRxiv 2021.08.12.454141; doi: https://doi.org/10.1101/2021.08.12.454141
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Overexpression of the SETD2 WW domain inhibits the phosphor-IWS1/SETD2 interaction and the oncogenic AKT/IWS1 RNA splicing program
Georgios I. Laliotis, Evangelia Chavdoul, Vollter Anastas, Satishkumar Singh, Adam D. Kenney, Samir Acharya, Jacob S. Yount, Lalit Sehgal, Philip N. Tsichlis
bioRxiv 2021.08.12.454141; doi: https://doi.org/10.1101/2021.08.12.454141

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