ColabFold - Making protein folding accessible to all

Milot Mirdita; Sergey Ovchinnikov; Martin Steinegger

doi:10.1101/2021.08.15.456425

Summary

ColabFold is an easy-to-use Notebook based environment for fast and convenient protein structure predictions. Its structure prediction is powered by AlphaFold2 and RoseTTAFold combined with a fast multiple sequence alignment generation stage using MMseqs2. MMseqs2’s MSAs produce more accurate predictions while being ~16 faster compared to the AlphaFold2’s MSA stage. ColabFold also offers many advanced features, such as homo- and hetero-complex modeling and exposes AlphaFold2 internals. When coupled with Google Colab, ColabFold becomes a free and accessible platform for protein folding that does not require any installation or expensive hardware.

Code ColabFold is free open-source (MIT) [1] software available at https://github.com/sokrypton/ColabFold.

Contact milot.mirdita{at}mpibpc.mpg.de, so{at}fas.harvard.edu, martin.steinegger{at}snu.ac.kr

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

https://github.com/sokrypton/ColabFold

The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.