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Goal-centered representations in the human hippocampus

Jordan Crivelli-Decker, Alex Clarke, View ORCID ProfileSeongmin A. Park, Derek J. Huffman, Erie Boorman, Charan Ranganath
doi: https://doi.org/10.1101/2021.08.18.456881
Jordan Crivelli-Decker
1Center for Neuroscience, University of California, Davis, USA
2Department of Psychology, University of California, Davis, USA
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  • For correspondence: jecrivellidecker@ucdavis.edu
Alex Clarke
4Department of Psychology, University of Cambridge, UK
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Seongmin A. Park
1Center for Neuroscience, University of California, Davis, USA
3Center for Mind and Brain, University of California, Davis, USA
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  • ORCID record for Seongmin A. Park
Derek J. Huffman
1Center for Neuroscience, University of California, Davis, USA
5Department of Psychology, Colby College, USA
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Erie Boorman
1Center for Neuroscience, University of California, Davis, USA
3Center for Mind and Brain, University of California, Davis, USA
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Charan Ranganath
1Center for Neuroscience, University of California, Davis, USA
2Department of Psychology, University of California, Davis, USA
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Abstract

Recent work in cognitive and systems neuroscience has suggested that the hippocampus might support planning, imagination, and navigation by forming “cognitive maps” that capture the structure of physical spaces, tasks, and situations. Critically, navigation involves planning within a context and disambiguating similar contexts to reach a goal. We examined hippocampal activity patterns in humans during a goal-directed navigation task to examine how contextual and goal information are incorporated in the construction and execution of navigational plans. Results demonstrate that, during planning, the hippocampus carries a context-specific representation of a future goal. Importantly, this effect could not be explained by stimulus or spatial information alone. During navigation, we observed reinstatement of activity patterns in the hippocampus ahead of participants’ required actions, which was strongest for behaviorally relevant points in the sequence. These results suggest that, rather than simply representing overlapping associations, hippocampal activity patterns are powerfully shaped by context and goals.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • Figures updated, additional citations, and minor tweaks based on editorial comments.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license.
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Posted September 07, 2021.
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Goal-centered representations in the human hippocampus
Jordan Crivelli-Decker, Alex Clarke, Seongmin A. Park, Derek J. Huffman, Erie Boorman, Charan Ranganath
bioRxiv 2021.08.18.456881; doi: https://doi.org/10.1101/2021.08.18.456881
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Goal-centered representations in the human hippocampus
Jordan Crivelli-Decker, Alex Clarke, Seongmin A. Park, Derek J. Huffman, Erie Boorman, Charan Ranganath
bioRxiv 2021.08.18.456881; doi: https://doi.org/10.1101/2021.08.18.456881

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