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Lacking social support is associated with structural divergences in hippocampus-default network co-variation patterns

Chris Zajner, Nathan Spreng, Danilo Bzdok
doi: https://doi.org/10.1101/2021.08.19.456949
Chris Zajner
1McConnell Brain Imaging Centre (BIC), Montreal Neurological Institute (MNI), Faculty of Medicine, McGill University, Montreal, Canada
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Nathan Spreng
1McConnell Brain Imaging Centre (BIC), Montreal Neurological Institute (MNI), Faculty of Medicine, McGill University, Montreal, Canada
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Danilo Bzdok
1McConnell Brain Imaging Centre (BIC), Montreal Neurological Institute (MNI), Faculty of Medicine, McGill University, Montreal, Canada
2Department of Biomedical Engineering, Faculty of Medicine, McGill University, Montreal, Canada
3Mila - Quebec Artificial Intelligence Institute, Montreal, Canada
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  • For correspondence: danilo.bzdok@mcgill.ca
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Abstract

Elaborate social interaction is a pivotal asset of the human species. The complexity of people’s social lives may constitute the dominating factor in the vibrancy of many individuals’ environment. The neural substrates linked to social cognition thus appear especially susceptible when people endure periods of social isolation: here, we zoom in on the systematic inter-relationships between two such neural substrates, the allocortical hippocampus (HC) and the neocortical default network (DN). Previous human social neuroscience studies have focused on the DN, while HC subfields have been studied in most detail in rodents and monkeys. To bring into contact these two separate research streams, we directly quantified how DN subregions are coherently co-expressed with specific HC subfields in the context of social isolation. A two-pronged decomposition of structural brain scans from ∼40,000 UK Biobank participants linked lack of social support to mostly lateral subregions in the DN patterns. This lateral DN association co-occurred with HC patterns that implicated especially subiculum, presubiculum, CA2, CA3, and dentate gyrus. Overall, the subregion divergences within spatially overlapping signatures of HC-DN co-variation followed a clear segregation divide into the left and right brain hemispheres. Separable regimes of structural HC-DN co-variation also showed distinct associations with the genetic predisposition for lacking social support at the population level.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted August 19, 2021.
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Lacking social support is associated with structural divergences in hippocampus-default network co-variation patterns
Chris Zajner, Nathan Spreng, Danilo Bzdok
bioRxiv 2021.08.19.456949; doi: https://doi.org/10.1101/2021.08.19.456949
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Lacking social support is associated with structural divergences in hippocampus-default network co-variation patterns
Chris Zajner, Nathan Spreng, Danilo Bzdok
bioRxiv 2021.08.19.456949; doi: https://doi.org/10.1101/2021.08.19.456949

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