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Sequence grammar underlying unfolding and phase separation of globular proteins

View ORCID ProfileKiersten M. Ruff, Yoon Hee Choi, View ORCID ProfileDezerae Cox, Angelique R. Ormsby, Yoochan Myung, View ORCID ProfileDavid B. Ascher, View ORCID ProfileSheena E. Radford, View ORCID ProfileRohit V. Pappu, View ORCID ProfileDanny M. Hatters
doi: https://doi.org/10.1101/2021.08.20.457073
Kiersten M. Ruff
1Department of Biomedical Engineering, Center for Science & Engineering of Living Systems, Washington University in St. Louis, St. Louis, MO 63130, USA
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  • ORCID record for Kiersten M. Ruff
Yoon Hee Choi
2Department of Biochemistry and Pharmacology; and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, VIC 3010. Australia
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Dezerae Cox
2Department of Biochemistry and Pharmacology; and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, VIC 3010. Australia
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Angelique R. Ormsby
2Department of Biochemistry and Pharmacology; and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, VIC 3010. Australia
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Yoochan Myung
3Computational Biology and Clinical Informatics, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia
4Structural Biology and Bioinformatics, Department of Biochemistry and Pharmacology, University of Melbourne, Melbourne, Victoria, Australia
5Systems and Computational Biology, Bio21 Institute, University of Melbourne, Melbourne, Victoria, Australia
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David B. Ascher
3Computational Biology and Clinical Informatics, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia
4Structural Biology and Bioinformatics, Department of Biochemistry and Pharmacology, University of Melbourne, Melbourne, Victoria, Australia
5Systems and Computational Biology, Bio21 Institute, University of Melbourne, Melbourne, Victoria, Australia
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Sheena E. Radford
6Astbury Centre for Structural and Molecular Biology, School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK
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  • ORCID record for Sheena E. Radford
Rohit V. Pappu
1Department of Biomedical Engineering, Center for Science & Engineering of Living Systems, Washington University in St. Louis, St. Louis, MO 63130, USA
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  • For correspondence: pappu@wustl.edu dhatters@unimelb.edu.au
Danny M. Hatters
2Department of Biochemistry and Pharmacology; and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, VIC 3010. Australia
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  • ORCID record for Danny M. Hatters
  • For correspondence: pappu@wustl.edu dhatters@unimelb.edu.au
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Article Information

doi 
https://doi.org/10.1101/2021.08.20.457073
History 
  • May 6, 2022.

Article Versions

  • Version 1 (August 20, 2021 - 08:02).
  • You are viewing Version 2, the most recent version of this article.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Kiersten M. Ruff1,§,
  2. Yoon Hee Choi2,§,
  3. Dezerae Cox2,
  4. Angelique R. Ormsby2,
  5. Yoochan Myung3,4,5,
  6. David B. Ascher3,4,5,
  7. Sheena E. Radford6,
  8. Rohit V. Pappu1,† and
  9. Danny M. Hatters2,†
  1. 1Department of Biomedical Engineering, Center for Science & Engineering of Living Systems, Washington University in St. Louis, St. Louis, MO 63130, USA
  2. 2Department of Biochemistry and Pharmacology; and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, VIC 3010. Australia
  3. 3Computational Biology and Clinical Informatics, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia
  4. 4Structural Biology and Bioinformatics, Department of Biochemistry and Pharmacology, University of Melbourne, Melbourne, Victoria, Australia
  5. 5Systems and Computational Biology, Bio21 Institute, University of Melbourne, Melbourne, Victoria, Australia
  6. 6Astbury Centre for Structural and Molecular Biology, School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK
  1. ↵†Corresponding authors: R.V. Pappu (pappu{at}wustl.edu), D.M. Hatters (dhatters{at}unimelb.edu.au)
  1. ↵§ Equal contributions

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Sequence grammar underlying unfolding and phase separation of globular proteins
Kiersten M. Ruff, Yoon Hee Choi, Dezerae Cox, Angelique R. Ormsby, Yoochan Myung, David B. Ascher, Sheena E. Radford, Rohit V. Pappu, Danny M. Hatters
bioRxiv 2021.08.20.457073; doi: https://doi.org/10.1101/2021.08.20.457073
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Sequence grammar underlying unfolding and phase separation of globular proteins
Kiersten M. Ruff, Yoon Hee Choi, Dezerae Cox, Angelique R. Ormsby, Yoochan Myung, David B. Ascher, Sheena E. Radford, Rohit V. Pappu, Danny M. Hatters
bioRxiv 2021.08.20.457073; doi: https://doi.org/10.1101/2021.08.20.457073

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