Sequence grammar underlying unfolding and phase separation of globular proteins

Kiersten M. Ruff; Yoon Hee Choi; Dezerae Cox; Angelique R. Ormsby; Yoochan Myung; David B. Ascher; Sheena E. Radford; Rohit V. Pappu; Danny M. Hatters

doi:10.1101/2021.08.20.457073

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Sequence grammar underlying unfolding and phase separation of globular proteins

View ORCID ProfileKiersten M. Ruff, Yoon Hee Choi, View ORCID ProfileDezerae Cox, Angelique R. Ormsby, Yoochan Myung, View ORCID ProfileDavid B. Ascher, View ORCID ProfileSheena E. Radford, View ORCID ProfileRohit V. Pappu, View ORCID ProfileDanny M. Hatters

doi: https://doi.org/10.1101/2021.08.20.457073

Kiersten M. Ruff

1Department of Biomedical Engineering, Center for Science & Engineering of Living Systems, Washington University in St. Louis, St. Louis, MO 63130, USA

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ORCID record for Kiersten M. Ruff

Yoon Hee Choi

2Department of Biochemistry and Pharmacology; and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, VIC 3010. Australia

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Dezerae Cox

2Department of Biochemistry and Pharmacology; and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, VIC 3010. Australia

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ORCID record for Dezerae Cox

Angelique R. Ormsby

2Department of Biochemistry and Pharmacology; and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, VIC 3010. Australia

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Yoochan Myung

3Computational Biology and Clinical Informatics, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia

4Structural Biology and Bioinformatics, Department of Biochemistry and Pharmacology, University of Melbourne, Melbourne, Victoria, Australia

5Systems and Computational Biology, Bio21 Institute, University of Melbourne, Melbourne, Victoria, Australia

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David B. Ascher

3Computational Biology and Clinical Informatics, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia

4Structural Biology and Bioinformatics, Department of Biochemistry and Pharmacology, University of Melbourne, Melbourne, Victoria, Australia

5Systems and Computational Biology, Bio21 Institute, University of Melbourne, Melbourne, Victoria, Australia

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Sheena E. Radford

6Astbury Centre for Structural and Molecular Biology, School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK

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ORCID record for Sheena E. Radford

Rohit V. Pappu

1Department of Biomedical Engineering, Center for Science & Engineering of Living Systems, Washington University in St. Louis, St. Louis, MO 63130, USA

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For correspondence: pappu@wustl.edu dhatters@unimelb.edu.au

Danny M. Hatters

2Department of Biochemistry and Pharmacology; and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, VIC 3010. Australia

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ORCID record for Danny M. Hatters
For correspondence: pappu@wustl.edu dhatters@unimelb.edu.au

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Sequence grammar underlying unfolding and phase separation of globular proteins

Kiersten M. Ruff, Yoon Hee Choi, Dezerae Cox, Angelique R. Ormsby, Yoochan Myung, David B. Ascher, Sheena E. Radford, Rohit V. Pappu, Danny M. Hatters

bioRxiv 2021.08.20.457073; doi: https://doi.org/10.1101/2021.08.20.457073

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Sequence grammar underlying unfolding and phase separation of globular proteins

Kiersten M. Ruff, Yoon Hee Choi, Dezerae Cox, Angelique R. Ormsby, Yoochan Myung, David B. Ascher, Sheena E. Radford, Rohit V. Pappu, Danny M. Hatters

bioRxiv 2021.08.20.457073; doi: https://doi.org/10.1101/2021.08.20.457073

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