A deep mutational scanning platform to characterize the fitness landscape of anti-CRISPR proteins

Tobias Stadelmann; Daniel Heid; Michael Jendrusch; Jan Mathony; Stéphane Rosset; Bruno E. Correia; Dominik Niopek

doi:10.1101/2021.08.21.457204

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A deep mutational scanning platform to characterize the fitness landscape of anti-CRISPR proteins

Tobias Stadelmann, Daniel Heid, Michael Jendrusch, Jan Mathony, Stéphane Rosset, Bruno E. Correia, Dominik Niopek

doi: https://doi.org/10.1101/2021.08.21.457204

Tobias Stadelmann

1Center for Synthetic Biology, Technical University of Darmstadt, Darmstadt, 64287, Germany

2Department of Biology, Technical University of Darmstadt, Darmstadt, 64287, Germany

3Black Forest Life Sciences Laboratory, FRO eV, Ohlsbach, 77797, Germany

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Daniel Heid

3Black Forest Life Sciences Laboratory, FRO eV, Ohlsbach, 77797, Germany

4Synthetic Biology Group, BioQuant Center of Heidelberg University, 69120 Heidelberg, Germany

5European Molecular Biology Laboratory (EMBL), 69117, Heidelberg, Germany

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Michael Jendrusch

4Synthetic Biology Group, BioQuant Center of Heidelberg University, 69120 Heidelberg, Germany

5European Molecular Biology Laboratory (EMBL), 69117, Heidelberg, Germany

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Jan Mathony

1Center for Synthetic Biology, Technical University of Darmstadt, Darmstadt, 64287, Germany

2Department of Biology, Technical University of Darmstadt, Darmstadt, 64287, Germany

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Stéphane Rosset

6Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, CH-1015, Switzerland

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Bruno E. Correia

6Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, CH-1015, Switzerland

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Dominik Niopek

1Center for Synthetic Biology, Technical University of Darmstadt, Darmstadt, 64287, Germany

2Department of Biology, Technical University of Darmstadt, Darmstadt, 64287, Germany

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For correspondence: dominik.niopek@tu-darmstadt.de

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A deep mutational scanning platform to characterize the fitness landscape of anti-CRISPR proteins

Tobias Stadelmann, Daniel Heid, Michael Jendrusch, Jan Mathony, Stéphane Rosset, Bruno E. Correia, Dominik Niopek

bioRxiv 2021.08.21.457204; doi: https://doi.org/10.1101/2021.08.21.457204

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A deep mutational scanning platform to characterize the fitness landscape of anti-CRISPR proteins

Tobias Stadelmann, Daniel Heid, Michael Jendrusch, Jan Mathony, Stéphane Rosset, Bruno E. Correia, Dominik Niopek

bioRxiv 2021.08.21.457204; doi: https://doi.org/10.1101/2021.08.21.457204

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