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Beyond dimension reduction: Stable electric fields emerge from and allow representational drift

View ORCID ProfileDimitris A. Pinotsis, Earl K. Miller
doi: https://doi.org/10.1101/2021.08.22.457247
Dimitris A. Pinotsis
1Centre for Mathematical Neuroscience and Psychology and Department of Psychology, City —University of London, London EC1V 0HB, United Kingdom
2The Picower Institute for Learning & Memory and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
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  • For correspondence: pinotsis@mit.edu
Earl K. Miller
2The Picower Institute for Learning & Memory and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
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Abstract

It is known that the exact neurons maintaining a given memory (the neural ensemble) change from trial to trial. This raises the question of how the brain achieves stability in the face of this representational drift. Here, we demonstrate that this stability emerges at the level of the electric fields that arise from neural activity. We show that electric fields carry information about working memory content. The electric fields, in turn, can act as “guard rails” that funnel higher dimensional variable neural activity along stable lower dimensional routes. We obtained the latent space associated with each memory. We then confirmed the stability of the electric field by mapping the latent space to different cortical patches (that comprise a neural ensemble) and reconstructing information flow between patches. Stable electric fields can allow latent states to be transferred between brain areas, in accord with modern engram theory.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted January 04, 2022.
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Beyond dimension reduction: Stable electric fields emerge from and allow representational drift
Dimitris A. Pinotsis, Earl K. Miller
bioRxiv 2021.08.22.457247; doi: https://doi.org/10.1101/2021.08.22.457247
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Beyond dimension reduction: Stable electric fields emerge from and allow representational drift
Dimitris A. Pinotsis, Earl K. Miller
bioRxiv 2021.08.22.457247; doi: https://doi.org/10.1101/2021.08.22.457247

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