Spectral fiber-photometry derives hemoglobin concentration changes for accurate measurement of fluorescent sensor activity

Wei-Ting Zhang; Tzu-Hao Harry Chao; Yue Yang; Tzu-Wen Wang; Sung-Ho Lee; Esteban A. Oyarzabal; Jingheng Zhou; Randy Nonneman; Nicolas C. Pegard; Hongtu Zhu; Guohong Cui; Yen-Yu Ian Shih

doi:10.1101/2021.08.23.457372

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Spectral fiber-photometry derives hemoglobin concentration changes for accurate measurement of fluorescent sensor activity

Wei-Ting Zhang, Tzu-Hao Harry Chao, Yue Yang, Tzu-Wen Wang, Sung-Ho Lee, Esteban A. Oyarzabal, Jingheng Zhou, Randy Nonneman, Nicolas C. Pegard, Hongtu Zhu, Guohong Cui, View ORCID ProfileYen-Yu Ian Shih

doi: https://doi.org/10.1101/2021.08.23.457372

Wei-Ting Zhang

1Center for Animal MRI, University of North Carolina at Chapel Hill

2Biomedical Research Imaging Center, University of North Carolina at Chapel Hill

3Department of Neurology, University of North Carolina at Chapel Hill

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Tzu-Hao Harry Chao

1Center for Animal MRI, University of North Carolina at Chapel Hill

2Biomedical Research Imaging Center, University of North Carolina at Chapel Hill

3Department of Neurology, University of North Carolina at Chapel Hill

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Yue Yang

1Center for Animal MRI, University of North Carolina at Chapel Hill

2Biomedical Research Imaging Center, University of North Carolina at Chapel Hill

3Department of Neurology, University of North Carolina at Chapel Hill

4Department of Biostatistics, University of North Carolina at Chapel Hill

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Tzu-Wen Wang

1Center for Animal MRI, University of North Carolina at Chapel Hill

2Biomedical Research Imaging Center, University of North Carolina at Chapel Hill

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Sung-Ho Lee

1Center for Animal MRI, University of North Carolina at Chapel Hill

2Biomedical Research Imaging Center, University of North Carolina at Chapel Hill

3Department of Neurology, University of North Carolina at Chapel Hill

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Esteban A. Oyarzabal

1Center for Animal MRI, University of North Carolina at Chapel Hill

2Biomedical Research Imaging Center, University of North Carolina at Chapel Hill

3Department of Neurology, University of North Carolina at Chapel Hill

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Jingheng Zhou

5In vivo Neurobiology Group, Neurobiology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health

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Randy Nonneman

1Center for Animal MRI, University of North Carolina at Chapel Hill

2Biomedical Research Imaging Center, University of North Carolina at Chapel Hill

3Department of Neurology, University of North Carolina at Chapel Hill

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Nicolas C. Pegard

6Department of Applied Physical Sciences, UNC Neuroscience Center, University of North Carolina at Chapel Hill

7Department of Biomedical Engineering, University of North Carolina at Chapel Hill

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Hongtu Zhu

2Biomedical Research Imaging Center, University of North Carolina at Chapel Hill

4Department of Biostatistics, University of North Carolina at Chapel Hill

8Department of Computer Science, University of North Carolina at Chapel Hill

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Guohong Cui

5In vivo Neurobiology Group, Neurobiology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health

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For correspondence: shihy@unc.edu cuig@mail.nih.gov

Yen-Yu Ian Shih

1Center for Animal MRI, University of North Carolina at Chapel Hill

2Biomedical Research Imaging Center, University of North Carolina at Chapel Hill

3Department of Neurology, University of North Carolina at Chapel Hill

7Department of Biomedical Engineering, University of North Carolina at Chapel Hill

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ORCID record for Yen-Yu Ian Shih
For correspondence: shihy@unc.edu cuig@mail.nih.gov

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Spectral fiber-photometry derives hemoglobin concentration changes for accurate measurement of fluorescent sensor activity

Wei-Ting Zhang, Tzu-Hao Harry Chao, Yue Yang, Tzu-Wen Wang, Sung-Ho Lee, Esteban A. Oyarzabal, Jingheng Zhou, Randy Nonneman, Nicolas C. Pegard, Hongtu Zhu, Guohong Cui, Yen-Yu Ian Shih

bioRxiv 2021.08.23.457372; doi: https://doi.org/10.1101/2021.08.23.457372

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Spectral fiber-photometry derives hemoglobin concentration changes for accurate measurement of fluorescent sensor activity

Wei-Ting Zhang, Tzu-Hao Harry Chao, Yue Yang, Tzu-Wen Wang, Sung-Ho Lee, Esteban A. Oyarzabal, Jingheng Zhou, Randy Nonneman, Nicolas C. Pegard, Hongtu Zhu, Guohong Cui, Yen-Yu Ian Shih

bioRxiv 2021.08.23.457372; doi: https://doi.org/10.1101/2021.08.23.457372

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