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CRISPRi screens in human astrocytes elucidate regulators of distinct inflammatory reactive states
Kun Leng, Brendan Rooney, Hyosung Kim, Wenlong Xia, Mark Koontz, Mitchell Krawczyk, Ye Zhang, Erik M. Ullian, Stephen P.J. Fancy, Matthew S. Schrag, Ethan S. Lippmann, View ORCID ProfileMartin Kampmann
doi: https://doi.org/10.1101/2021.08.23.457400
Kun Leng
1Institute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, CA, USA
2Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA, USA
3Medical Scientist Training Program, University of California, San Francisco, San Francisco, CA, USA
Brendan Rooney
1Institute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, CA, USA
Hyosung Kim
4Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA. Department of Neurology, Vanderbilt University, Nashville, TN, United States
Wenlong Xia
5Departments of Neurology and Pediatrics, School of Medicine, University of California, San Francisco
Mark Koontz
6Department of Ophthalmology, School of Medicine, University of California, San Francisco
Mitchell Krawczyk
7Neuroscience Graduate Program, University of California, Los Angeles, Los Angeles, CA, USA
8Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA
Ye Zhang
8Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA
Erik M. Ullian
6Department of Ophthalmology, School of Medicine, University of California, San Francisco
Stephen P.J. Fancy
5Departments of Neurology and Pediatrics, School of Medicine, University of California, San Francisco
Matthew S. Schrag
9Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA
10Vanderbilt Memory and Alzheimer’s Center, Vanderbilt University Medical Center, Nashville, TN, USA
11Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA
Ethan S. Lippmann
4Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA. Department of Neurology, Vanderbilt University, Nashville, TN, United States
9Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA
10Vanderbilt Memory and Alzheimer’s Center, Vanderbilt University Medical Center, Nashville, TN, USA
11Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA
Martin Kampmann
1Institute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, CA, USA
12Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA
13Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA
14Chan Zuckerberg Biohub, San Francisco, CA, USA
Article usage
Posted August 24, 2021.
CRISPRi screens in human astrocytes elucidate regulators of distinct inflammatory reactive states
Kun Leng, Brendan Rooney, Hyosung Kim, Wenlong Xia, Mark Koontz, Mitchell Krawczyk, Ye Zhang, Erik M. Ullian, Stephen P.J. Fancy, Matthew S. Schrag, Ethan S. Lippmann, Martin Kampmann
bioRxiv 2021.08.23.457400; doi: https://doi.org/10.1101/2021.08.23.457400
CRISPRi screens in human astrocytes elucidate regulators of distinct inflammatory reactive states
Kun Leng, Brendan Rooney, Hyosung Kim, Wenlong Xia, Mark Koontz, Mitchell Krawczyk, Ye Zhang, Erik M. Ullian, Stephen P.J. Fancy, Matthew S. Schrag, Ethan S. Lippmann, Martin Kampmann
bioRxiv 2021.08.23.457400; doi: https://doi.org/10.1101/2021.08.23.457400
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