A novel multifunctional role for Hsp70 in binding post-translational modifications on client proteins

Nitika; Bo Zheng; Linhao Ruan; Jake T. Kline; Jacek Sikora; Mara Texeira Torres; Yuhao Wang; Jade E. Takakuwa; Romain Huguet; Cinzia Klemm; Verónica A. Segarra; Matthew J. Winters; Peter M. Pryciak; Peter H. Thorpe; Kazuo Tatebayashi; Rong Li; Luca Fornelli; Andrew W. Truman

doi:10.1101/2021.08.25.457671

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A novel multifunctional role for Hsp70 in binding post-translational modifications on client proteins

View ORCID ProfileNitika, Bo Zheng, Linhao Ruan, Jake T. Kline, Jacek Sikora, Mara Texeira Torres, Yuhao Wang, Jade E. Takakuwa, Romain Huguet, Cinzia Klemm, View ORCID ProfileVerónica A. Segarra, Matthew J. Winters, Peter M. Pryciak, Peter H. Thorpe, Kazuo Tatebayashi, Rong Li, Luca Fornelli, View ORCID ProfileAndrew W. Truman

doi: https://doi.org/10.1101/2021.08.25.457671

Nitika

1Department of Biological Sciences, The University of North Carolina at Charlotte, Charlotte, NC 28223 USA

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For correspondence: [email protected] [email protected]

Bo Zheng

1Department of Biological Sciences, The University of North Carolina at Charlotte, Charlotte, NC 28223 USA

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Linhao Ruan

2Center for Cell Dynamics and Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205 USA.

3Biochemistry, Cellular and Molecular Biology (BCMB) Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD 21287 USA.

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Jake T. Kline

6Department of Biology, University of Oklahoma, Norman, OK 73019 USA

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Jacek Sikora

7AbbVie Inc., La Grange, IL 60525 USA

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Mara Texeira Torres

8School of Biological and Chemical Sciences, Queen Mary University, London E1 4NS UK

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Yuhao Wang

2Center for Cell Dynamics and Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205 USA.

3Biochemistry, Cellular and Molecular Biology (BCMB) Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD 21287 USA.

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Jade E. Takakuwa

1Department of Biological Sciences, The University of North Carolina at Charlotte, Charlotte, NC 28223 USA

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Romain Huguet

9Thermo Scientific, San Jose, CA 95134 USA

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Cinzia Klemm

8School of Biological and Chemical Sciences, Queen Mary University, London E1 4NS UK

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Verónica A. Segarra

10Department of Biology, High Point University, High Point, NC 27268 USA

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Matthew J. Winters

11Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605 USA

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Peter M. Pryciak

11Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605 USA

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Peter H. Thorpe

9Thermo Scientific, San Jose, CA 95134 USA

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Kazuo Tatebayashi

12Laboratory of Molecular Genetics, Frontier Research Unit, Institute of Medical Science, The University of Tokyo 108-8639, Tokyo, Japan

13Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo 113-0033, Japan

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Rong Li

2Center for Cell Dynamics and Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205 USA.

3Biochemistry, Cellular and Molecular Biology (BCMB) Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD 21287 USA.

4Mechanobiology Institute and Department of Biological Sciences, National University of Singapore, Singapore 117411

5Department of Chemical and Biomolecular Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD 21218 USA

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Luca Fornelli

6Department of Biology, University of Oklahoma, Norman, OK 73019 USA

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Andrew W. Truman

1Department of Biological Sciences, The University of North Carolina at Charlotte, Charlotte, NC 28223 USA

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For correspondence: [email protected] [email protected]

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A novel multifunctional role for Hsp70 in binding post-translational modifications on client proteins

Nitika, Bo Zheng, Linhao Ruan, Jake T. Kline, Jacek Sikora, Mara Texeira Torres, Yuhao Wang, Jade E. Takakuwa, Romain Huguet, Cinzia Klemm, Verónica A. Segarra, Matthew J. Winters, Peter M. Pryciak, Peter H. Thorpe, Kazuo Tatebayashi, Rong Li, Luca Fornelli, Andrew W. Truman

bioRxiv 2021.08.25.457671; doi: https://doi.org/10.1101/2021.08.25.457671

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