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Alterations in rhythmic and non-rhythmic resting-state EEG activity and their link to cognition in older age

View ORCID ProfileElena Cesnaite, View ORCID ProfilePaul Steinfath, View ORCID ProfileMina Jamshidi Idaji, View ORCID ProfileTilman Stephani, View ORCID ProfileDeniz Kumral, View ORCID ProfileStefan Haufe, View ORCID ProfileChristian Sander, View ORCID ProfileTilman Hensch, View ORCID ProfileUlrich Hegerl, View ORCID ProfileSteffi Riedel-Heller, View ORCID ProfileSusanne Röhr, View ORCID ProfileMatthias L. Schroeter, View ORCID ProfileA. Veronica Witte, View ORCID ProfileArno Villringer, View ORCID ProfileVadim V. Nikulin
doi: https://doi.org/10.1101/2021.08.26.457768
Elena Cesnaite
1Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
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  • For correspondence: cesnaite@cbs.mpg.de
Paul Steinfath
1Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
2International Max Planck Research School NeuroCom, Leipzig, Germany
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Mina Jamshidi Idaji
1Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
2International Max Planck Research School NeuroCom, Leipzig, Germany
3Machine Learning Group, Technical University Berlin, Berlin, Germany
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Tilman Stephani
1Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
2International Max Planck Research School NeuroCom, Leipzig, Germany
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Deniz Kumral
1Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
4Department of Psychology, Neuropsychology, University of Freiburg, Germany
5Institute of Psychology, Department of Clinical Psychology and Psychotherapy, University of Freiburg, Germany
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Stefan Haufe
6Berlin Center for Advanced Neuroimaging, Charité – Universitätsmedizin Berlin, Berlin, Germany
7Bernstein Center for Computational Neuroscience Berlin, Berlin, Germany
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Christian Sander
8Department of Psychiatry and Psychotherapy, University of Leipzig Medical Center, Leipzig, Germany
9LIFE – Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany
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Tilman Hensch
8Department of Psychiatry and Psychotherapy, University of Leipzig Medical Center, Leipzig, Germany
9LIFE – Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany
10IUBH International University, Erfurt, Germany
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Ulrich Hegerl
9LIFE – Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany
11Department of Psychiatry, Psychosomatics and Psychotherapy, Goethe University Frankfurt, Frankfurt, Germany
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Steffi Riedel-Heller
9LIFE – Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany
12Institute of Social Medicine, Occupational Health and Public Health, University of Leipzig, Leipzig, Germany
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Susanne Röhr
9LIFE – Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany
12Institute of Social Medicine, Occupational Health and Public Health, University of Leipzig, Leipzig, Germany
13Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland
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Matthias L. Schroeter
1Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
14Clinic of Cognitive Neurology, University Hospital Leipzig, Leipzig, Germany
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A. Veronica Witte
1Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
14Clinic of Cognitive Neurology, University Hospital Leipzig, Leipzig, Germany
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Arno Villringer
1Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
14Clinic of Cognitive Neurology, University Hospital Leipzig, Leipzig, Germany
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Vadim V. Nikulin
1Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
15Centre for Cognition and Decision Making, Institute for Cognitive Neuroscience, HSE University, Moscow, Russian Federation
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Abstract

While many structural and biochemical changes in the brain have been previously associated with aging, the findings concerning electrophysiological signatures, reflecting functional properties of neuronal networks, remain rather controversial. To try resolve this issue, we took advantage of a large population study (N=1703) and comprehensively investigated the association of multiple EEG biomarkers (power of alpha and theta oscillations, individual alpha peak frequency (IAF), the slope of 1/f power spectral decay), aging, and aging and cognitive performance. Cognitive performance was captured with three factors representing processing speed, episodic memory, and interference resolution. Our results show that not only did IAF decline with age but it was also associated with interference resolution over multiple cortical areas. To a weaker extent, 1/f slope of the PSD showed age-related reductions, mostly in frontal brain regions. Finally, alpha power was negatively associated with the speed of processing in the right frontal lobe, despite the absence of age-related alterations. Our results thus demonstrate that multiple electrophysiological features, as well as their interplay, should be considered when investigating the association between age, neuronal activity, and cognitive performance.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • The revised version includes Figure 4 that was missing in the previous version.

  • 1 https://www.uke.de/english/departments-institutes/institutes/neurophysiology-and-pathophysiology/research/research-groups/index.html

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Alterations in rhythmic and non-rhythmic resting-state EEG activity and their link to cognition in older age
Elena Cesnaite, Paul Steinfath, Mina Jamshidi Idaji, Tilman Stephani, Deniz Kumral, Stefan Haufe, Christian Sander, Tilman Hensch, Ulrich Hegerl, Steffi Riedel-Heller, Susanne Röhr, Matthias L. Schroeter, A. Veronica Witte, Arno Villringer, Vadim V. Nikulin
bioRxiv 2021.08.26.457768; doi: https://doi.org/10.1101/2021.08.26.457768
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Alterations in rhythmic and non-rhythmic resting-state EEG activity and their link to cognition in older age
Elena Cesnaite, Paul Steinfath, Mina Jamshidi Idaji, Tilman Stephani, Deniz Kumral, Stefan Haufe, Christian Sander, Tilman Hensch, Ulrich Hegerl, Steffi Riedel-Heller, Susanne Röhr, Matthias L. Schroeter, A. Veronica Witte, Arno Villringer, Vadim V. Nikulin
bioRxiv 2021.08.26.457768; doi: https://doi.org/10.1101/2021.08.26.457768

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