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Microstructural Properties of Human Brain Revealed by Fractional Anisotropy can Predict the After-effect of Intermittent Theta Burst Stimulation

View ORCID ProfileIkko Kimura, Hiroki Oishi, Masamichi J Hayashi, Kaoru Amano
doi: https://doi.org/10.1101/2021.08.30.458153
Ikko Kimura
1Center for Information and Neural Networks (CiNet), Advanced ICT Research Institute, National Institute of Information and Communications Technology, Suita 565-0871, Japan
2Graduate School of Frontier Biosciences, Osaka University, Suita 565-0871, Japan
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  • For correspondence: ikimura-osk@umin.ac.jp kaoru_amano@ipc.i.u-tokyo.ac.jp
Hiroki Oishi
1Center for Information and Neural Networks (CiNet), Advanced ICT Research Institute, National Institute of Information and Communications Technology, Suita 565-0871, Japan
2Graduate School of Frontier Biosciences, Osaka University, Suita 565-0871, Japan
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Masamichi J Hayashi
1Center for Information and Neural Networks (CiNet), Advanced ICT Research Institute, National Institute of Information and Communications Technology, Suita 565-0871, Japan
2Graduate School of Frontier Biosciences, Osaka University, Suita 565-0871, Japan
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Kaoru Amano
1Center for Information and Neural Networks (CiNet), Advanced ICT Research Institute, National Institute of Information and Communications Technology, Suita 565-0871, Japan
2Graduate School of Frontier Biosciences, Osaka University, Suita 565-0871, Japan
3Graduate School of Information Science and Technology, The University of Tokyo, Tokyo 113-8656, Japan
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  • For correspondence: ikimura-osk@umin.ac.jp kaoru_amano@ipc.i.u-tokyo.ac.jp
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Abstract

Intermittent theta burst stimulation (iTBS) delivered by transcranial magnetic stimulation (TMS) produces a long term potentiation (LTP)-like after-effect useful for investigations of cortical function and of potential therapeutic value. However, the iTBS-evoked after-effect over the primary motor cortex (M1) as measured by changes in motor evoked potential (MEP) amplitude exhibits a largely unexplained variability across individuals. Here, we present evidence that individual differences in white and grey matter microstructural properties revealed by fractional anisotropy (FA) predict the magnitude of the iTBS-induced after-effect over M1. The MEP amplitude change in the early phase (5–10 min) post-iTBS was associated with FA values in white matter tracts such as right superior longitudinal fasciculus and corpus callosum. In contrast, the MEP amplitude change in the late phase (15–30 min) post-iTBS was associated with FA in grey matter, primarily in right frontal cortex. These results suggest that the microstructural properties of regions connected directly or indirectly to the target region (M1) are crucial determinants of the iTBS after-effect. FA values indicative of these microstructural differences can predict the potential effectiveness of rTMS for both investigational use and clinical application.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.
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Posted August 31, 2021.
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Microstructural Properties of Human Brain Revealed by Fractional Anisotropy can Predict the After-effect of Intermittent Theta Burst Stimulation
Ikko Kimura, Hiroki Oishi, Masamichi J Hayashi, Kaoru Amano
bioRxiv 2021.08.30.458153; doi: https://doi.org/10.1101/2021.08.30.458153
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Microstructural Properties of Human Brain Revealed by Fractional Anisotropy can Predict the After-effect of Intermittent Theta Burst Stimulation
Ikko Kimura, Hiroki Oishi, Masamichi J Hayashi, Kaoru Amano
bioRxiv 2021.08.30.458153; doi: https://doi.org/10.1101/2021.08.30.458153

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