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Stability of spectral estimates in resting-state magnetoencephalography: recommendations for minimal data duration with neuroanatomical specificity

View ORCID ProfileAlex I. Wiesman, View ORCID ProfileJason Da Silva Castanheira, View ORCID ProfileSylvain Baillet
doi: https://doi.org/10.1101/2021.08.31.458384
Alex I. Wiesman
1McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal QC, Canada
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  • For correspondence: alexander.wiesman@mail.mcgill.ca
Jason Da Silva Castanheira
1McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal QC, Canada
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Sylvain Baillet
1McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal QC, Canada
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Abstract

The principle of resting-state paradigms is appealing and practical for collecting data from impaired patients and special populations, especially if data collection times can be minimized. To achieve this goal, researchers need to ensure estimated signal features of interest are robust. In electro- and magnetoencephalography (EEG, MEG) we are not aware of studies of the minimal length of recording required to yield a robust one-session snapshot of the frequency-spectrum derivatives that are typically used to characterize the complex dynamics of the brain’s resting-state. We aimed to fill this knowledge gap by studying the stability of common spectral measures of resting-state MEG source time series obtained from large samples of single-session recordings from shared data repositories featuring different recording conditions and instrument technologies (OMEGA: N = 107; Cam-CAN: N = 50). We discovered that the rhythmic and arrhythmic spectral properties of intrinsic brain activity can be robustly estimated in most cortical regions when derived from relatively short recordings of 30-s to 120-s of resting-state data, regardless of instrument technology and resting-state paradigm. Using an adapted leave-one-out approach and Bayesian analysis, we also provide evidence that the stability of spectral features over time is unaffected by age, sex, handedness, and general cognitive function. In summary, short MEG sessions are sufficient to yield robust estimates of frequency-defined brain activity during resting-state. This study may help guide future empirical designs in the field, particularly when recording times need to be minimized, such as with patient or special populations.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted September 01, 2021.
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Stability of spectral estimates in resting-state magnetoencephalography: recommendations for minimal data duration with neuroanatomical specificity
Alex I. Wiesman, Jason Da Silva Castanheira, Sylvain Baillet
bioRxiv 2021.08.31.458384; doi: https://doi.org/10.1101/2021.08.31.458384
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Stability of spectral estimates in resting-state magnetoencephalography: recommendations for minimal data duration with neuroanatomical specificity
Alex I. Wiesman, Jason Da Silva Castanheira, Sylvain Baillet
bioRxiv 2021.08.31.458384; doi: https://doi.org/10.1101/2021.08.31.458384

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