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Novel genome assemblies and Evolutionary Dynamics of North American Anopheles mosquitoes

View ORCID ProfileCory A. Henderson, Karen Kemirembe, Sage McKeand, Christina Bergey, View ORCID ProfileJason L. Rasgon
doi: https://doi.org/10.1101/2021.08.31.458407
Cory A. Henderson
1Departments of Entomology and Disease Epidemiology, The Pennsylvania State University, University Park, PA, United States of America, 16801
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Karen Kemirembe
1Departments of Entomology and Disease Epidemiology, The Pennsylvania State University, University Park, PA, United States of America, 16801
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Sage McKeand
1Departments of Entomology and Disease Epidemiology, The Pennsylvania State University, University Park, PA, United States of America, 16801
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Christina Bergey
2Department of Genetics, Rutgers University, New Brunswick, NJ, United States of America, 08901
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Jason L. Rasgon
1Departments of Entomology and Disease Epidemiology, The Pennsylvania State University, University Park, PA, United States of America, 16801
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  • For correspondence: jlr54@psu.edu
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ABSTRACT

Anopheles mosquitoes are the principal vectors for malaria and lymphatic filariasis, and evidence for arboviral transmission under laboratory and natural contexts has been demonstrated. Vector management approaches require an understanding of the ecological, epidemiological, and biological context of the species in question, and increased interest in gene drive systems for vector control applications has resulted in an increased need for genome assemblies from understudied mosquito species. While the genomes for many Anopheles species have been sequenced, North American Anopheles taxa have been neglected. In this study we present novel genome assemblies for the North American species An. crucians, An. freeborni, An. albimanus, and An. quadrimaculatus, and examine the evolutionary relationship between these species. We identified 790 shared single copy orthologs between the newly sequenced genomes and created a phylogeny using 673 of the orthologs, identifying 525 orthologs with evidence for positive selection on at least one branch of the phylogeny. Gene ontology terms such as calcium ion signaling, histone binding, and protein acetylation were identified as being biased in the set of selected genes. These novel genome sequences will be useful in developing our understanding of the diverse biological traits that drive vectorial capacity in anophelines.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • Reference Numbers: Bioproject ID PRJNA758127

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted August 31, 2021.
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Novel genome assemblies and Evolutionary Dynamics of North American Anopheles mosquitoes
Cory A. Henderson, Karen Kemirembe, Sage McKeand, Christina Bergey, Jason L. Rasgon
bioRxiv 2021.08.31.458407; doi: https://doi.org/10.1101/2021.08.31.458407
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Novel genome assemblies and Evolutionary Dynamics of North American Anopheles mosquitoes
Cory A. Henderson, Karen Kemirembe, Sage McKeand, Christina Bergey, Jason L. Rasgon
bioRxiv 2021.08.31.458407; doi: https://doi.org/10.1101/2021.08.31.458407

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