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The vaccinia-based Sementis Copenhagen Vector COVID-19 vaccine induces broad and durable cellular and humoral immune responses

Preethi Eldi, Tamara H. Cooper, Natalie A. Prow, Liang Liu, Gary K. Heinemann, Voueleng J. Zhang, Abigail D. Trinidad, Ruth Marian Guzman-Genuino, Peter Wulff, Leanne M. Hobbs, Kerrilyn R. Diener, John D. Hayball
doi: https://doi.org/10.1101/2021.09.06.459206
Preethi Eldi
1Experimental Therapeutics Laboratory, Clinical and Health Science Unit, University of South Australia, Adelaide, SA, 5000, Australia
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  • For correspondence: preethi.eldi@unisa.edu.au john.hayball@unisa.edu.au
Tamara H. Cooper
1Experimental Therapeutics Laboratory, Clinical and Health Science Unit, University of South Australia, Adelaide, SA, 5000, Australia
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Natalie A. Prow
1Experimental Therapeutics Laboratory, Clinical and Health Science Unit, University of South Australia, Adelaide, SA, 5000, Australia
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Liang Liu
1Experimental Therapeutics Laboratory, Clinical and Health Science Unit, University of South Australia, Adelaide, SA, 5000, Australia
4Gene Technologies Group, Department of Molecular Biology, Research, CSL Limited, Parkville, VIC, 3010, Australia
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Gary K. Heinemann
1Experimental Therapeutics Laboratory, Clinical and Health Science Unit, University of South Australia, Adelaide, SA, 5000, Australia
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Voueleng J. Zhang
1Experimental Therapeutics Laboratory, Clinical and Health Science Unit, University of South Australia, Adelaide, SA, 5000, Australia
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Abigail D. Trinidad
1Experimental Therapeutics Laboratory, Clinical and Health Science Unit, University of South Australia, Adelaide, SA, 5000, Australia
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Ruth Marian Guzman-Genuino
2Sementis Limited, Hackney, SA, 5069, Australia
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Peter Wulff
2Sementis Limited, Hackney, SA, 5069, Australia
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Leanne M. Hobbs
1Experimental Therapeutics Laboratory, Clinical and Health Science Unit, University of South Australia, Adelaide, SA, 5000, Australia
2Sementis Limited, Hackney, SA, 5069, Australia
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Kerrilyn R. Diener
1Experimental Therapeutics Laboratory, Clinical and Health Science Unit, University of South Australia, Adelaide, SA, 5000, Australia
3Robinson Research Institute and Adelaide Medical School, The University of Adelaide, Adelaide, SA, 5005, Australia
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John D. Hayball
1Experimental Therapeutics Laboratory, Clinical and Health Science Unit, University of South Australia, Adelaide, SA, 5000, Australia
2Sementis Limited, Hackney, SA, 5069, Australia
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  • For correspondence: preethi.eldi@unisa.edu.au john.hayball@unisa.edu.au
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Article Information

doi 
https://doi.org/10.1101/2021.09.06.459206
History 
  • September 7, 2021.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Preethi Eldi1,*,
  2. Tamara H. Cooper1,5,
  3. Natalie A. Prow1,5,
  4. Liang Liu1,4,
  5. Gary K. Heinemann1,
  6. Voueleng J. Zhang1,
  7. Abigail D. Trinidad1,
  8. Ruth Marian Guzman-Genuino2,
  9. Peter Wulff2,
  10. Leanne M. Hobbs1,2,
  11. Kerrilyn R. Diener1,3 and
  12. John D. Hayball1,2,*
  1. 1Experimental Therapeutics Laboratory, Clinical and Health Science Unit, University of South Australia, Adelaide, SA, 5000, Australia
  2. 2Sementis Limited, Hackney, SA, 5069, Australia
  3. 3Robinson Research Institute and Adelaide Medical School, The University of Adelaide, Adelaide, SA, 5005, Australia
  4. 4Gene Technologies Group, Department of Molecular Biology, Research, CSL Limited, Parkville, VIC, 3010, Australia
  1. ↵*Corresponding authors: Dr Preethi Eldi; Clinical and Health Sciences Unit, University of South Australia, GPO Box 2471, Adelaide, SA, 5001, Australia. Email: preethi.eldi{at}unisa.edu.au; Prof John Hayball; Sementis Limited, 25 North Tce, Hackney, SA, 5069, Australia. Email: john.hayball{at}unisa.edu.au
  1. ↵5 These authors contributed equally to this work.

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The vaccinia-based Sementis Copenhagen Vector COVID-19 vaccine induces broad and durable cellular and humoral immune responses
Preethi Eldi, Tamara H. Cooper, Natalie A. Prow, Liang Liu, Gary K. Heinemann, Voueleng J. Zhang, Abigail D. Trinidad, Ruth Marian Guzman-Genuino, Peter Wulff, Leanne M. Hobbs, Kerrilyn R. Diener, John D. Hayball
bioRxiv 2021.09.06.459206; doi: https://doi.org/10.1101/2021.09.06.459206
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The vaccinia-based Sementis Copenhagen Vector COVID-19 vaccine induces broad and durable cellular and humoral immune responses
Preethi Eldi, Tamara H. Cooper, Natalie A. Prow, Liang Liu, Gary K. Heinemann, Voueleng J. Zhang, Abigail D. Trinidad, Ruth Marian Guzman-Genuino, Peter Wulff, Leanne M. Hobbs, Kerrilyn R. Diener, John D. Hayball
bioRxiv 2021.09.06.459206; doi: https://doi.org/10.1101/2021.09.06.459206

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