Abstract
Reconsolidation enables the activity-dependent modification of memory traces and has been used to reverse addiction, fear memory, and pain hypersensitivity in animal models. We demonstrate that non-ionotropic NMDA receptor signalling in the spinal dorsal horn is sufficient to reverse pain hypersensitivity and necessary for pain modulation by spinal reconsolidation. These findings reveal a key process by which reconsolidation disrupts memory traces that may be exploited in the treatment of pain and other disorders.
Competing Interest Statement
The authors have declared no competing interest.
Footnotes
Disclosure AV-101 was provided by VistaGen Therapeutics. VistaGen Therapeutics did not provide input or influence on the design, analysis, or reporting of results.
Copyright
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