New Results
Germline Missense Variants in CDC20 Result in Aberrant Mitotic Progression and Familial Cancer
View ORCID ProfileOwen J. Chen, Ester Castellsagué, View ORCID ProfileMohamed Moustafa-Kamal, Javad Nadaf, Barbara Rivera, Somayyeh Fahiminiya, Yilin Wang, Isabelle Gamache, Caterina Pacifico, Lai Jiang, Jian Carrot-Zhang, Leora Witkowski, Albert M. Berghuis, Stefan Schoenberger, Dominik Schneider, Susanne Bens, Reiner Siebert, Colin J. R. Stewart, Ziguo Zhang, William C. Chao, Celia M.T. Greenwood, David Barford, Marc Tischkowitz, Jacek Majewski, View ORCID ProfileWilliam D. Foulkes, View ORCID ProfileJose G. Teodoro
doi: https://doi.org/10.1101/2021.09.13.459529
Owen J. Chen
1Goodman Cancer Institute, McGill University, Montréal, Québec, Canada H3A 1A3
2Department of Biochemistry, McGill University, Montréal, Québec, Canada H3G 1Y6
Ester Castellsagué
3Department of Human Genetics, McGill University, Montréal, Québec, Canada H3A 0C7
4Department of Medical Genetics, Lady Davis Institute, Segal Cancer Centre, Jewish General Hospital, Montréal, Québec, Canada H3T 1E2
5Translational Research Laboratory, Catalan Institute of Oncology, Bellvitge Institute for Biomedical Research, L’Hospitalet de Llobregat, Barcelona, Spain 08908
Mohamed Moustafa-Kamal
1Goodman Cancer Institute, McGill University, Montréal, Québec, Canada H3A 1A3
2Department of Biochemistry, McGill University, Montréal, Québec, Canada H3G 1Y6
Javad Nadaf
6McGill University and Génome Québec Innovation Centre, Montréal, Québec, Canada H3A 0G1
Barbara Rivera
3Department of Human Genetics, McGill University, Montréal, Québec, Canada H3A 0C7
4Department of Medical Genetics, Lady Davis Institute, Segal Cancer Centre, Jewish General Hospital, Montréal, Québec, Canada H3T 1E2
Somayyeh Fahiminiya
7Research Institute of the McGill University Health Centre, Montréal, Québec, Canada H3H 2R9
Yilin Wang
1Goodman Cancer Institute, McGill University, Montréal, Québec, Canada H3A 1A3
2Department of Biochemistry, McGill University, Montréal, Québec, Canada H3G 1Y6
Isabelle Gamache
1Goodman Cancer Institute, McGill University, Montréal, Québec, Canada H3A 1A3
Caterina Pacifico
1Goodman Cancer Institute, McGill University, Montréal, Québec, Canada H3A 1A3
8Department of Biology, McGill University, Montréal, Québec, Canada H3A 1B1
Lai Jiang
9Lady Davis Institute, Jewish General Hospital, Montréal, Québec, Canada H3T 1E2
10Department of Epidemiology, Biostatistics & Occupational Health, McGill University, Montréal, Québec, Canada H3A 1A2
Jian Carrot-Zhang
3Department of Human Genetics, McGill University, Montréal, Québec, Canada H3A 0C7
7Research Institute of the McGill University Health Centre, Montréal, Québec, Canada H3H 2R9
Leora Witkowski
3Department of Human Genetics, McGill University, Montréal, Québec, Canada H3A 0C7
4Department of Medical Genetics, Lady Davis Institute, Segal Cancer Centre, Jewish General Hospital, Montréal, Québec, Canada H3T 1E2
Albert M. Berghuis
2Department of Biochemistry, McGill University, Montréal, Québec, Canada H3G 1Y6
11Groupe de Recherche Axé sur la Structure des Protéines, McGill University, Montréal, Québec, Canada H3G 0B1
Stefan Schoenberger
12Pediatric Hematology and Oncology, Children’s Hospital, University of Bonn, Bonn, Germany 53113
Dominik Schneider
13Clinic of Pediatrics, Dortmund Municipal Hospital, Dortmund, Germany 44137
Susanne Bens
14Institute of Human Genetics, University of Ulm & Ulm University Hospital, Ulm, Germany 89081
Reiner Siebert
14Institute of Human Genetics, University of Ulm & Ulm University Hospital, Ulm, Germany 89081
Colin J. R. Stewart
15Department of Histopathology, King Edward Memorial Hospital, and School for Women’s and Infants’ Health, University of Western Australia, Perth, Australia 6008
Ziguo Zhang
16Institute of Cancer Research, London, United Kingdom SM2 5NG
William C. Chao
17Faculty of Health Sciences, University of Macau, Macau SAR, China
Celia M.T. Greenwood
8Department of Biology, McGill University, Montréal, Québec, Canada H3A 1B1
10Department of Epidemiology, Biostatistics & Occupational Health, McGill University, Montréal, Québec, Canada H3A 1A2
18Departments of Oncology and Human Genetics, McGill University, Montréal, Québec, Canada H4A 3T2
David Barford
16Institute of Cancer Research, London, United Kingdom SM2 5NG
Marc Tischkowitz
19Department of Medical Genetics, University of Cambridge, Cambridge, United Kingdom CB2 0QQ
Jacek Majewski
3Department of Human Genetics, McGill University, Montréal, Québec, Canada H3A 0C7
7Research Institute of the McGill University Health Centre, Montréal, Québec, Canada H3H 2R9
William D. Foulkes
3Department of Human Genetics, McGill University, Montréal, Québec, Canada H3A 0C7
4Department of Medical Genetics, Lady Davis Institute, Segal Cancer Centre, Jewish General Hospital, Montréal, Québec, Canada H3T 1E2
20Program in Cancer Genetics, Department of Oncology and Human Genetics, McGill University, Montréal, Québec, Canada H4A 3T2
21Department of Medical Genetics and Cancer Research Program, Research Institute of the McGill University Health Centre, Montréal, Québec, Canada H3H 2R9
Jose G. Teodoro
1Goodman Cancer Institute, McGill University, Montréal, Québec, Canada H3A 1A3
2Department of Biochemistry, McGill University, Montréal, Québec, Canada H3G 1Y6
22Department of Microbiology and Immunology, Montréal, Québec, Canada H3A 2B4
Article usage
Posted September 14, 2021.
Germline Missense Variants in CDC20 Result in Aberrant Mitotic Progression and Familial Cancer
Owen J. Chen, Ester Castellsagué, Mohamed Moustafa-Kamal, Javad Nadaf, Barbara Rivera, Somayyeh Fahiminiya, Yilin Wang, Isabelle Gamache, Caterina Pacifico, Lai Jiang, Jian Carrot-Zhang, Leora Witkowski, Albert M. Berghuis, Stefan Schoenberger, Dominik Schneider, Susanne Bens, Reiner Siebert, Colin J. R. Stewart, Ziguo Zhang, William C. Chao, Celia M.T. Greenwood, David Barford, Marc Tischkowitz, Jacek Majewski, William D. Foulkes, Jose G. Teodoro
bioRxiv 2021.09.13.459529; doi: https://doi.org/10.1101/2021.09.13.459529
Germline Missense Variants in CDC20 Result in Aberrant Mitotic Progression and Familial Cancer
Owen J. Chen, Ester Castellsagué, Mohamed Moustafa-Kamal, Javad Nadaf, Barbara Rivera, Somayyeh Fahiminiya, Yilin Wang, Isabelle Gamache, Caterina Pacifico, Lai Jiang, Jian Carrot-Zhang, Leora Witkowski, Albert M. Berghuis, Stefan Schoenberger, Dominik Schneider, Susanne Bens, Reiner Siebert, Colin J. R. Stewart, Ziguo Zhang, William C. Chao, Celia M.T. Greenwood, David Barford, Marc Tischkowitz, Jacek Majewski, William D. Foulkes, Jose G. Teodoro
bioRxiv 2021.09.13.459529; doi: https://doi.org/10.1101/2021.09.13.459529
Subject Area
Subject Areas
- Biochemistry (11740)
- Bioengineering (8750)
- Bioinformatics (29189)
- Biophysics (14967)
- Cancer Biology (12093)
- Cell Biology (17410)
- Clinical Trials (138)
- Developmental Biology (9420)
- Ecology (14178)
- Epidemiology (2067)
- Evolutionary Biology (18301)
- Genetics (12239)
- Genomics (16797)
- Immunology (11865)
- Microbiology (28070)
- Molecular Biology (11583)
- Neuroscience (60953)
- Paleontology (451)
- Pathology (1870)
- Pharmacology and Toxicology (3238)
- Physiology (4957)
- Plant Biology (10425)
- Synthetic Biology (2884)
- Systems Biology (7338)
- Zoology (1651)