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Multiphase Organization Is a Second Phase Transition Within Multi-Component Biomolecular Condensates

Konstantinos Mazarakos, View ORCID ProfileHuan-Xiang Zhou
doi: https://doi.org/10.1101/2021.09.13.460104
Konstantinos Mazarakos
aDepartment of Physics, University of Illinois at Chicago, Chicago, IL 60607, United State
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Huan-Xiang Zhou
aDepartment of Physics, University of Illinois at Chicago, Chicago, IL 60607, United State
bDepartment of Chemistry, University of Illinois at Chicago, Chicago, IL 60607, United State
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  • ORCID record for Huan-Xiang Zhou
  • For correspondence: hzhou43@uic.edu
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ABSTRACT

We present a mean-field theory for the multiphase organization of multi-component biomolecular condensates and validate the theory by molecular dynamics simulations of model mixtures. A first phase transition results in the separation of the dense phase from the bulk phase. In a second phase transition, the components in the dense phase demix to localize in separate regions that attach to each other. The second phase transition occurs when the strength of cross-species attraction goes below the mean strength of the self-attraction of the individual species and reaches a critical value. At a given strength of cross-species attraction, both of the phase transitions can be observed by decreasing temperature, leading first to phase separation and then to demixing of the dense phase. The theory and simulations establish the disparity in strength between self and cross-species attraction as a main driver for the multiphase organization of multi-component biomolecular condensates.

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Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted September 16, 2021.
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Multiphase Organization Is a Second Phase Transition Within Multi-Component Biomolecular Condensates
Konstantinos Mazarakos, Huan-Xiang Zhou
bioRxiv 2021.09.13.460104; doi: https://doi.org/10.1101/2021.09.13.460104
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Multiphase Organization Is a Second Phase Transition Within Multi-Component Biomolecular Condensates
Konstantinos Mazarakos, Huan-Xiang Zhou
bioRxiv 2021.09.13.460104; doi: https://doi.org/10.1101/2021.09.13.460104

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