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Social isolation is linked to classical risk factors of Alzheimer’s disease-related dementias

Kimia Shafighi, Sylvia Villeneuve, View ORCID ProfilePedro Rosa-Neto, AmanPreet Badhwar, Judes Poirier, Vaibhav Sharma, View ORCID ProfileYasser Iturria-Medina, Patricia P Silveira, Laurette Dube, David Glahn, Danilo Bzdok
doi: https://doi.org/10.1101/2021.09.13.460121
Kimia Shafighi
1Department of Biomedical Engineering, Faculty of Medicine, McGill University, Montreal, Canada
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  • For correspondence: kimia.shafighi@mail.mcgill.ca
Sylvia Villeneuve
2Neurology and Neurosurgery Department, Montreal Neurological Institute (MNI), Faculty of Medicine, McGill University, Montreal, Canada
3McConnell Brain Imaging Centre (BIC), MNI, Faculty of Medicine, McGill University, Montreal, Canada
4Department of Psychiatry, McGill University, H3A 1A1, Montreal, Quebec, Canada
5Douglas Mental Health University Institute, Studies on Prevention of Alzheimer’s Disease (StoP-AD) Centre, H4H 1R3, Montreal, Quebec, Canada
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Pedro Rosa-Neto
5Douglas Mental Health University Institute, Studies on Prevention of Alzheimer’s Disease (StoP-AD) Centre, H4H 1R3, Montreal, Quebec, Canada
6Translational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, Alzheimer’s Disease Research Unit, Montreal, Canada
7Le Centre intégré universitaire de santé et de services sociaux (CIUSSS) de l’Ouest-de-l’Île-de-Montréal, Montréal, Canada
8Department of Neurology and Neurosurgery, Psychiatry and Pharmacology and Therapeutics, McGill University, Montreal, Canada
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  • ORCID record for Pedro Rosa-Neto
AmanPreet Badhwar
9Département de pharmacologie et physiologie, Faculté de médecine, Université de Montréal, Montréal, Canada
10Centre de recherche de l’Institut universitaire de gériatrie de Montréal (CRIUGM), Montréal, Canada
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Judes Poirier
11Centre for Studies in the Prevention of Alzheimer’s Disease, Douglas Mental Health Institute, McGill University, Montreal, Canada
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Vaibhav Sharma
1Department of Biomedical Engineering, Faculty of Medicine, McGill University, Montreal, Canada
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Yasser Iturria-Medina
2Neurology and Neurosurgery Department, Montreal Neurological Institute (MNI), Faculty of Medicine, McGill University, Montreal, Canada
3McConnell Brain Imaging Centre (BIC), MNI, Faculty of Medicine, McGill University, Montreal, Canada
12Ludmer Centre for Neuroinformatics and Mental Health, McGill University, Montreal, Canada
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  • ORCID record for Yasser Iturria-Medina
Patricia P Silveira
4Department of Psychiatry, McGill University, H3A 1A1, Montreal, Quebec, Canada
12Ludmer Centre for Neuroinformatics and Mental Health, McGill University, Montreal, Canada
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Laurette Dube
13Desautels Faculty of Management, McGill Center for the Convergence of Health and Economics, McGill University, Montreal, QC, Canada
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David Glahn
14Tommy Fuss Center for Neuropsychiatric Disease Research, Department of Psychiatry, Boston Children’s Hospital, Boston, MA, USA
15Department of Psychiatry, Harvard Medical School, Boston, MA, USA
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Danilo Bzdok
1Department of Biomedical Engineering, Faculty of Medicine, McGill University, Montreal, Canada
3McConnell Brain Imaging Centre (BIC), MNI, Faculty of Medicine, McGill University, Montreal, Canada
16School of Computer Science, McGill University, Montreal, Canada
17Mila - Quebec Artificial Intelligence Institute, Montreal, Canada
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Article Information

doi 
https://doi.org/10.1101/2021.09.13.460121
History 
  • September 15, 2021.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Kimia Shafighi1,*,
  2. Sylvia Villeneuve2,3,4,5,
  3. Pedro Rosa-Neto5,6,7,8,
  4. AmanPreet Badhwar9,10,
  5. Judes Poirier11,
  6. Vaibhav Sharma1,
  7. Yasser Iturria-Medina2,3,12,
  8. Patricia P Silveira4,12,
  9. Laurette Dube13,
  10. David Glahn14,15 and
  11. Danilo Bzdok1,3,16,17
  1. 1Department of Biomedical Engineering, Faculty of Medicine, McGill University, Montreal, Canada
  2. 2Neurology and Neurosurgery Department, Montreal Neurological Institute (MNI), Faculty of Medicine, McGill University, Montreal, Canada
  3. 3McConnell Brain Imaging Centre (BIC), MNI, Faculty of Medicine, McGill University, Montreal, Canada
  4. 4Department of Psychiatry, McGill University, H3A 1A1, Montreal, Quebec, Canada
  5. 5Douglas Mental Health University Institute, Studies on Prevention of Alzheimer’s Disease (StoP-AD) Centre, H4H 1R3, Montreal, Quebec, Canada
  6. 6Translational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, Alzheimer’s Disease Research Unit, Montreal, Canada
  7. 7Le Centre intégré universitaire de santé et de services sociaux (CIUSSS) de l’Ouest-de-l’Île-de-Montréal, Montréal, Canada
  8. 8Department of Neurology and Neurosurgery, Psychiatry and Pharmacology and Therapeutics, McGill University, Montreal, Canada
  9. 9Département de pharmacologie et physiologie, Faculté de médecine, Université de Montréal, Montréal, Canada
  10. 10Centre de recherche de l’Institut universitaire de gériatrie de Montréal (CRIUGM), Montréal, Canada
  11. 11Centre for Studies in the Prevention of Alzheimer’s Disease, Douglas Mental Health Institute, McGill University, Montreal, Canada
  12. 12Ludmer Centre for Neuroinformatics and Mental Health, McGill University, Montreal, Canada
  13. 13Desautels Faculty of Management, McGill Center for the Convergence of Health and Economics, McGill University, Montreal, QC, Canada
  14. 14Tommy Fuss Center for Neuropsychiatric Disease Research, Department of Psychiatry, Boston Children’s Hospital, Boston, MA, USA
  15. 15Department of Psychiatry, Harvard Medical School, Boston, MA, USA
  16. 16School of Computer Science, McGill University, Montreal, Canada
  17. 17Mila - Quebec Artificial Intelligence Institute, Montreal, Canada
  1. ↵* Corresponding author; email: kimia.shafighi{at}mail.mcgill.ca
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Social isolation is linked to classical risk factors of Alzheimer’s disease-related dementias
Kimia Shafighi, Sylvia Villeneuve, Pedro Rosa-Neto, AmanPreet Badhwar, Judes Poirier, Vaibhav Sharma, Yasser Iturria-Medina, Patricia P Silveira, Laurette Dube, David Glahn, Danilo Bzdok
bioRxiv 2021.09.13.460121; doi: https://doi.org/10.1101/2021.09.13.460121
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Social isolation is linked to classical risk factors of Alzheimer’s disease-related dementias
Kimia Shafighi, Sylvia Villeneuve, Pedro Rosa-Neto, AmanPreet Badhwar, Judes Poirier, Vaibhav Sharma, Yasser Iturria-Medina, Patricia P Silveira, Laurette Dube, David Glahn, Danilo Bzdok
bioRxiv 2021.09.13.460121; doi: https://doi.org/10.1101/2021.09.13.460121

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