Inhibition of sodium conductance by cannabigerol contributes to a reduction of neuronal dorsal root ganglion excitability

Mohammad-Reza Ghovanloo; Mark Estacion; Peng Zhao; Sulayman Dib-Hajj; Stephen G. Waxman

doi:10.1101/2021.09.14.460359

Article Information

doi

https://doi.org/10.1101/2021.09.14.460359

History

September 16, 2021.

The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

Author Information

Mohammad-Reza Ghovanloo,
Mark Estacion,
Peng Zhao,
Sulayman Dib-Hajj and
Stephen G. Waxman*

¹Department of Neurology, Yale University School of Medicine, New Haven, CT, USA
²Center for Neuroscience & Regeneration Research, Yale University, West Haven, CT, USA
³Neuro-rehabilitation Research Center, Veterans Affairs Connecticut Healthcare System, West Haven, CT, USA

↵*Corresponding author: Dr. Stephen G. Waxman, E-mail: stephen.waxman{at}yale.edu.

Author contributions, M. -R. Ghovanloo: designed study, designed protocols/experiments, assembled data, performed experiments, wrote simulation code, performed modeling/simulations, assay development, data analysis, figure making, wrote manuscript, data interpretation, and assisted to conceiving of experiments.
M. Estacion: helped with experiments, analysis, and provided thoughtful conversations/ideas.
P. Zhao: performed DRG culture.
S. Dib-Hajj: conceived the experiments and revised the manuscript critically.
S. G. Waxman: performed conceptualization, funding acquisition, provided resources, data curation, formal analysis, supervision, validation, investigation, methodology, writing and review and editing of manuscript, and provided project administration.