Intronization enhances expression of S-protein and other transgenes challenged by cryptic splicing

Kärt Tomberg; Liliana Antunes; YangYang Pan; Jacob Hepkema; Dimitrios A. Garyfallos; Ahmed Mahfouz; Allan Bradley

doi:10.1101/2021.09.15.460454

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Intronization enhances expression of S-protein and other transgenes challenged by cryptic splicing

View ORCID ProfileKärt Tomberg, View ORCID ProfileLiliana Antunes, View ORCID ProfileYangYang Pan, View ORCID ProfileJacob Hepkema, View ORCID ProfileDimitrios A. Garyfallos, View ORCID ProfileAhmed Mahfouz, View ORCID ProfileAllan Bradley

doi: https://doi.org/10.1101/2021.09.15.460454

Kärt Tomberg

1CITIID, Department of Medicine, University of Cambridge, Cambridge, UK

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For correspondence: kt474@cam.ac.uk ab2592@cam.ac.uk

Liliana Antunes

1CITIID, Department of Medicine, University of Cambridge, Cambridge, UK

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YangYang Pan

1CITIID, Department of Medicine, University of Cambridge, Cambridge, UK

2College of Veterinary Medicine, Shanxi Agricultural University, Taigu, China

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Jacob Hepkema

3Wellcome Sanger Institute, Hinxton, UK

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Dimitrios A. Garyfallos

1CITIID, Department of Medicine, University of Cambridge, Cambridge, UK

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Ahmed Mahfouz

4Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands

5Delft Bioinformatics Lab, Delft University of Technology, Delft, The Netherlands

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Allan Bradley

1CITIID, Department of Medicine, University of Cambridge, Cambridge, UK

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For correspondence: kt474@cam.ac.uk ab2592@cam.ac.uk

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Posted September 15, 2021.

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Intronization enhances expression of S-protein and other transgenes challenged by cryptic splicing

Kärt Tomberg, Liliana Antunes, YangYang Pan, Jacob Hepkema, Dimitrios A. Garyfallos, Ahmed Mahfouz, Allan Bradley

bioRxiv 2021.09.15.460454; doi: https://doi.org/10.1101/2021.09.15.460454

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Intronization enhances expression of S-protein and other transgenes challenged by cryptic splicing

Kärt Tomberg, Liliana Antunes, YangYang Pan, Jacob Hepkema, Dimitrios A. Garyfallos, Ahmed Mahfouz, Allan Bradley

bioRxiv 2021.09.15.460454; doi: https://doi.org/10.1101/2021.09.15.460454

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