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Empowering rare variant burden-based gene-trait association studies via optimized computational predictor choice
View ORCID ProfileDa Kuang, Roujia Li, View ORCID ProfileYingzhou Wu, View ORCID ProfileJochen Weile, View ORCID ProfileRobert A. Hegele, View ORCID ProfileFrederick P. Roth
doi: https://doi.org/10.1101/2021.09.20.459182
Da Kuang
1Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada
2Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada
3Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON M5G 1X5, Canada
4Department of Computer Science, University of Toronto, Toronto, ON M5T 3A1, Canada
Roujia Li
1Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada
2Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada
3Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON M5G 1X5, Canada
4Department of Computer Science, University of Toronto, Toronto, ON M5T 3A1, Canada
Yingzhou Wu
1Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada
2Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada
3Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON M5G 1X5, Canada
4Department of Computer Science, University of Toronto, Toronto, ON M5T 3A1, Canada
Jochen Weile
1Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada
2Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada
3Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON M5G 1X5, Canada
4Department of Computer Science, University of Toronto, Toronto, ON M5T 3A1, Canada
Robert A. Hegele
5Departments of Medicine and Biochemistry, Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, ON, N6A 5B7 Canada
Frederick P. Roth
1Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada
2Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada
3Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON M5G 1X5, Canada
4Department of Computer Science, University of Toronto, Toronto, ON M5T 3A1, Canada
Posted September 22, 2022.
Empowering rare variant burden-based gene-trait association studies via optimized computational predictor choice
Da Kuang, Roujia Li, Yingzhou Wu, Jochen Weile, Robert A. Hegele, Frederick P. Roth
bioRxiv 2021.09.20.459182; doi: https://doi.org/10.1101/2021.09.20.459182
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