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Identifying The “Core” Transcriptome of SARS-CoV-2 Infected Cells

Elanood Tageldin Nour, Ryan Tran, Ayda Afravi, Xinyue Pei, Angela Davidian, View ORCID ProfilePavan Kadandale
doi: https://doi.org/10.1101/2021.09.22.461142
Elanood Tageldin Nour
University of California Irvine
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Ryan Tran
University of California Irvine
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Ayda Afravi
University of California Irvine
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Xinyue Pei
University of California Irvine
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Angela Davidian
University of California Irvine
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Pavan Kadandale
University of California Irvine
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  • ORCID record for Pavan Kadandale
  • For correspondence: pavan.k@uci.edu
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Abstract

In 2019, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) first emerged, causing the COVID-19 pandemic. Consequently, ongoing research has focused on better understanding the mechanisms underlying the symptoms of this disease. Although COVID-19 symptoms span a range of organ systems, the specific changes in gene regulation that lead to the variety of symptoms are still unclear. In our study, we used publicly available transcriptome data from previous studies on SARS-CoV-2 to identify commonly regulated genes across cardiomyocytes, human bronchial epithelial cells, alveolar type II cells, lung adenocarcinoma, human embryonic kidney cells, and patient samples. Additionally, using this common “core” transcriptome, we could identify the genes that were specifically and uniquely regulated in bronchial epithelial cells, embryonic kidney cells, or cardiomyocytes. For example, we found that genes related to cell metabolism were uniquely upregulated in kidney cells, providing us with the first mechanistic clue about specifically how kidney cells may be affected by SARS-CoV-2. Overall, our results uncover connections between the differential gene regulation in various cell types in response to the SARS-CoV-2 infection and help identify targets of potential therapeutics.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted September 23, 2021.
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Identifying The “Core” Transcriptome of SARS-CoV-2 Infected Cells
Elanood Tageldin Nour, Ryan Tran, Ayda Afravi, Xinyue Pei, Angela Davidian, Pavan Kadandale
bioRxiv 2021.09.22.461142; doi: https://doi.org/10.1101/2021.09.22.461142
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Identifying The “Core” Transcriptome of SARS-CoV-2 Infected Cells
Elanood Tageldin Nour, Ryan Tran, Ayda Afravi, Xinyue Pei, Angela Davidian, Pavan Kadandale
bioRxiv 2021.09.22.461142; doi: https://doi.org/10.1101/2021.09.22.461142

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