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Combinatorial G x G x E CRISPR screening and functional analysis highlights SLC25A39 in mitochondrial GSH transport
Xiaojian Shi, Bryn Reinstadler, Hardik Shah, Tsz-Leung To, Katie Byrne, Luanna Summer, Sarah E. Calvo, Olga Goldberger, View ORCID ProfileJohn G. Doench, View ORCID ProfileVamsi K. Mootha, View ORCID ProfileHongying Shen
doi: https://doi.org/10.1101/2021.09.22.461361
Xiaojian Shi
1Cellular and Molecular Physiology Department, Yale School of Medicine, New Haven, CT 06511, USA; Systems Biology Institute, Yale West Campus, West Haven, CT 06516, USA
Bryn Reinstadler
2Howard Hughes Medical Institute and Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
3Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
4Broad Institute, Cambridge, MA 02141, USA
Hardik Shah
2Howard Hughes Medical Institute and Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
3Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
4Broad Institute, Cambridge, MA 02141, USA
Tsz-Leung To
2Howard Hughes Medical Institute and Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
3Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
4Broad Institute, Cambridge, MA 02141, USA
Katie Byrne
1Cellular and Molecular Physiology Department, Yale School of Medicine, New Haven, CT 06511, USA; Systems Biology Institute, Yale West Campus, West Haven, CT 06516, USA
Luanna Summer
1Cellular and Molecular Physiology Department, Yale School of Medicine, New Haven, CT 06511, USA; Systems Biology Institute, Yale West Campus, West Haven, CT 06516, USA
Sarah E. Calvo
2Howard Hughes Medical Institute and Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
3Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
4Broad Institute, Cambridge, MA 02141, USA
Olga Goldberger
2Howard Hughes Medical Institute and Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
3Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
John G. Doench
4Broad Institute, Cambridge, MA 02141, USA
Vamsi K. Mootha
2Howard Hughes Medical Institute and Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
3Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
4Broad Institute, Cambridge, MA 02141, USA
Hongying Shen
1Cellular and Molecular Physiology Department, Yale School of Medicine, New Haven, CT 06511, USA; Systems Biology Institute, Yale West Campus, West Haven, CT 06516, USA
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Posted September 22, 2021.
Combinatorial G x G x E CRISPR screening and functional analysis highlights SLC25A39 in mitochondrial GSH transport
Xiaojian Shi, Bryn Reinstadler, Hardik Shah, Tsz-Leung To, Katie Byrne, Luanna Summer, Sarah E. Calvo, Olga Goldberger, John G. Doench, Vamsi K. Mootha, Hongying Shen
bioRxiv 2021.09.22.461361; doi: https://doi.org/10.1101/2021.09.22.461361
Combinatorial G x G x E CRISPR screening and functional analysis highlights SLC25A39 in mitochondrial GSH transport
Xiaojian Shi, Bryn Reinstadler, Hardik Shah, Tsz-Leung To, Katie Byrne, Luanna Summer, Sarah E. Calvo, Olga Goldberger, John G. Doench, Vamsi K. Mootha, Hongying Shen
bioRxiv 2021.09.22.461361; doi: https://doi.org/10.1101/2021.09.22.461361
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