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Characterizing pupil dynamics coupling to brain state fluctuation based on lateral hypothalamic activity

View ORCID ProfileKengo Takahashi, View ORCID ProfileFilip Sobczak, View ORCID ProfilePatricia Pais-Roldán, View ORCID ProfileXin Yu
doi: https://doi.org/10.1101/2021.09.22.461385
Kengo Takahashi
1High-Field Magnetic Resonance Department, Max Planck Institute for Biological Cybernetics, 72076 Tübingen, Germany
2Graduate Training Centre of Neuroscience, International Max Planck Research School (IMPRS), University of Tübingen, 72076 Tübingen, Germany
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Filip Sobczak
1High-Field Magnetic Resonance Department, Max Planck Institute for Biological Cybernetics, 72076 Tübingen, Germany
2Graduate Training Centre of Neuroscience, International Max Planck Research School (IMPRS), University of Tübingen, 72076 Tübingen, Germany
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Patricia Pais-Roldán
3Medical Imaging Physics, Institute of Neuroscience and Medicine (INM-4), Forschungszentrum Jülich, 52425 Jülich, Germany
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Xin Yu
4Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
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  • For correspondence: xyu9@mgh.harvard.edu
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Abstract

Pupil dynamics presents varied correlation features with brain activity under different vigilant levels. The modulation of brain state changes can arise from the lateral hypothalamus (LH), where diverse neuronal cell types contribute to arousal regulation in opposite directions via the anterior cingulate cortex (ACC). However, the relationship of the LH and pupil dynamics has seldom been investigated. Here, we performed local field potential (LFP) recordings at the LH and ACC, and the whole brain fMRI with simultaneous fiber photometry Ca2+ recording in the ACC, to evaluate their correlation with brain state-dependent pupil dynamics. Both LFP and functional MRI (fMRI) data showed opposite correlation features to pupil dynamics, demonstrating an LH activity-dependent manner. Our results demonstrate that the correlation of pupil dynamics with ACC LFP and whole-brain fMRI signals depends on LH activity, indicating a role of the latter in brain state regulation.

Competing Interest Statement

The authors have declared no competing interest.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted September 24, 2021.
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Characterizing pupil dynamics coupling to brain state fluctuation based on lateral hypothalamic activity
Kengo Takahashi, Filip Sobczak, Patricia Pais-Roldán, Xin Yu
bioRxiv 2021.09.22.461385; doi: https://doi.org/10.1101/2021.09.22.461385
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Characterizing pupil dynamics coupling to brain state fluctuation based on lateral hypothalamic activity
Kengo Takahashi, Filip Sobczak, Patricia Pais-Roldán, Xin Yu
bioRxiv 2021.09.22.461385; doi: https://doi.org/10.1101/2021.09.22.461385

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