New Results
Inflammasome activation in infected macrophages drives COVID-19 pathology
View ORCID ProfileEsen Sefik, View ORCID ProfileRihao Qu, Caroline Junqueira, Eleanna Kaffe, Haris Mirza, Jun Zhao, J. Richard Brewer, Ailin Han, View ORCID ProfileHolly R. Steach, Benjamin Israelow, Holly N. Blackburn, Sofia Velazquez, Y. Grace Chen, View ORCID ProfileStephanie Halene, View ORCID ProfileAkiko Iwasaki, View ORCID ProfileEric Meffre, Michel Nussenzweig, Judy Lieberman, Craig B. Wilen, View ORCID ProfileYuval Kluger, View ORCID ProfileRichard A. Flavell
doi: https://doi.org/10.1101/2021.09.27.461948
Esen Sefik
1Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA
Rihao Qu
1Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA
2Department of Pathology, Yale University School of Medicine, New Haven, CT, USA
Caroline Junqueira
3Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Boston, MA, USA
4Department of Pediatrics, Harvard Medical School, Boston, MA, USA
5Instituto René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, Minas Gerais, Brazil
Eleanna Kaffe
1Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA
Haris Mirza
1Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA
2Department of Pathology, Yale University School of Medicine, New Haven, CT, USA
Jun Zhao
1Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA
2Department of Pathology, Yale University School of Medicine, New Haven, CT, USA
J. Richard Brewer
1Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA
Ailin Han
1Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA
Holly R. Steach
1Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA
Benjamin Israelow
1Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA
Holly N. Blackburn
1Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA
10Department of Surgery, Yale University School of Medicine
Sofia Velazquez
1Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA
Y. Grace Chen
1Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA
Stephanie Halene
2Department of Pathology, Yale University School of Medicine, New Haven, CT, USA
6Section of Hematology, Yale Cancer Center and Department of Internal Medicine, Yale University School of Medicine, New Haven, CT
Akiko Iwasaki
1Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA
9Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT, USA
Eric Meffre
1Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA
Michel Nussenzweig
7Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA
9Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT, USA
Judy Lieberman
3Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Boston, MA, USA
4Department of Pediatrics, Harvard Medical School, Boston, MA, USA
Craig B. Wilen
1Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA
8Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, USA
Yuval Kluger
2Department of Pathology, Yale University School of Medicine, New Haven, CT, USA
Richard A. Flavell
1Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA
9Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT, USA
Article usage
Posted April 01, 2022.
Inflammasome activation in infected macrophages drives COVID-19 pathology
Esen Sefik, Rihao Qu, Caroline Junqueira, Eleanna Kaffe, Haris Mirza, Jun Zhao, J. Richard Brewer, Ailin Han, Holly R. Steach, Benjamin Israelow, Holly N. Blackburn, Sofia Velazquez, Y. Grace Chen, Stephanie Halene, Akiko Iwasaki, Eric Meffre, Michel Nussenzweig, Judy Lieberman, Craig B. Wilen, Yuval Kluger, Richard A. Flavell
bioRxiv 2021.09.27.461948; doi: https://doi.org/10.1101/2021.09.27.461948
Inflammasome activation in infected macrophages drives COVID-19 pathology
Esen Sefik, Rihao Qu, Caroline Junqueira, Eleanna Kaffe, Haris Mirza, Jun Zhao, J. Richard Brewer, Ailin Han, Holly R. Steach, Benjamin Israelow, Holly N. Blackburn, Sofia Velazquez, Y. Grace Chen, Stephanie Halene, Akiko Iwasaki, Eric Meffre, Michel Nussenzweig, Judy Lieberman, Craig B. Wilen, Yuval Kluger, Richard A. Flavell
bioRxiv 2021.09.27.461948; doi: https://doi.org/10.1101/2021.09.27.461948
Subject Area
Subject Areas
- Biochemistry (11745)
- Bioengineering (8752)
- Bioinformatics (29200)
- Biophysics (14972)
- Cancer Biology (12096)
- Cell Biology (17411)
- Clinical Trials (138)
- Developmental Biology (9421)
- Ecology (14182)
- Epidemiology (2067)
- Evolutionary Biology (18308)
- Genetics (12245)
- Genomics (16803)
- Immunology (11869)
- Microbiology (28085)
- Molecular Biology (11592)
- Neuroscience (60969)
- Paleontology (451)
- Pathology (1871)
- Pharmacology and Toxicology (3238)
- Physiology (4959)
- Plant Biology (10427)
- Synthetic Biology (2885)
- Systems Biology (7340)
- Zoology (1651)