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The structure of hippocampal CA1 interactions optimizes spatial coding across experience

View ORCID ProfileMichele Nardin, Jozsef Csicsvari, View ORCID ProfileGašper Tkačik, View ORCID ProfileCristina Savin
doi: https://doi.org/10.1101/2021.09.28.460602
Michele Nardin
aInstitute of Science and Technology Austria, AT-3400 Klosterneuburg, Austria
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Jozsef Csicsvari
aInstitute of Science and Technology Austria, AT-3400 Klosterneuburg, Austria
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Gašper Tkačik
aInstitute of Science and Technology Austria, AT-3400 Klosterneuburg, Austria
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Cristina Savin
bNew York University, New York NY-10003, USA
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  • For correspondence: cs5360@nyu.edu
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Abstract

Although much is known about how single neurons in the hippocampus represent an animal’s position, how cell-cell interactions contribute to spatial coding remains poorly understood. Using a novel statistical estimator and theoretical modeling, both developed in the framework of maximum entropy models, we reveal highly structured cell-to-cell interactions whose statistics depend on familiar vs. novel environment. In both conditions the circuit interactions optimize the encoding of spatial information, but for regimes that differ in the signal-to-noise ratio of their spatial inputs. Moreover, the topology of the interactions facilitates linear decodability, making the information easy to read out by downstream circuits. These findings suggest that the efficient coding hypothesis is not applicable only to individual neuron properties in the sensory periphery, but also to neural interactions in the central brain.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • The authors declare no competing interests.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted September 29, 2021.
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The structure of hippocampal CA1 interactions optimizes spatial coding across experience
Michele Nardin, Jozsef Csicsvari, Gašper Tkačik, Cristina Savin
bioRxiv 2021.09.28.460602; doi: https://doi.org/10.1101/2021.09.28.460602
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The structure of hippocampal CA1 interactions optimizes spatial coding across experience
Michele Nardin, Jozsef Csicsvari, Gašper Tkačik, Cristina Savin
bioRxiv 2021.09.28.460602; doi: https://doi.org/10.1101/2021.09.28.460602

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