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Gamma Entrainment Improves Synchronization Deficits in Dementia Patients

View ORCID ProfileMojtaba Lahijanian, View ORCID ProfileHamid Aghajan, Zahra Vahabi, Arshia Afzal
doi: https://doi.org/10.1101/2021.09.30.462389
Mojtaba Lahijanian
1Department of Electrical Engineering, Sharif University of Technology, Tehran, Iran
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Hamid Aghajan
1Department of Electrical Engineering, Sharif University of Technology, Tehran, Iran
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  • For correspondence: aghajan@ee.sharif.edu
Zahra Vahabi
2Department of Geriatric Medicine, Ziaeian Hospital, Tehran University of Medical Sciences, Tehran, Iran
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Arshia Afzal
1Department of Electrical Engineering, Sharif University of Technology, Tehran, Iran
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Abstract

Non-invasive gamma entrainment has shown promising results in alleviating cognitive symptoms of Alzheimer’s disease in mice and humans. In this study, we examine improvements in the synchronization characteristics of the brain’s oscillations induced by 40Hz auditory stimulation based on electroencephalography data recorded from a group of dementia patients. We observed that when the quality of entrainment surpasses a certain level, several indicators of brain synchronization significantly improve. Specifically, the entrained oscillatory activity maintains temporal phase stability in the frontal, parietal, and occipital regions, and persistent spatial phase coupling between them. In addition, notable theta-gamma phase-amplitude coupling is observed in these areas. Interestingly, a high theta power at rest predicts the quality of entrainment. We identify differentiating attributes of temporal/spatial synchronization and cross-frequency coupling in the data of two groups with entrained and non-entrained responses which point to enhanced network synchronization caused by entrainment and can explain its potential therapeutic effects.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • https://openneuro.org/datasets/ds003800/versions/1.0.0

  • https://openneuro.org/datasets/ds003805/versions/1.0.0

  • https://github.com/m-l-3/Gamma-Entrainment

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted October 10, 2021.
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Gamma Entrainment Improves Synchronization Deficits in Dementia Patients
Mojtaba Lahijanian, Hamid Aghajan, Zahra Vahabi, Arshia Afzal
bioRxiv 2021.09.30.462389; doi: https://doi.org/10.1101/2021.09.30.462389
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Gamma Entrainment Improves Synchronization Deficits in Dementia Patients
Mojtaba Lahijanian, Hamid Aghajan, Zahra Vahabi, Arshia Afzal
bioRxiv 2021.09.30.462389; doi: https://doi.org/10.1101/2021.09.30.462389

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