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Confirmatory Results

Measurements of EEG Alpha Peak Frequencies Over the Lifespan: Validating Target Ranges on an In-Clinic Platform

David Joffe, D S Oakley, View ORCID ProfileF Arese Lucini, F. X. Palermo
doi: https://doi.org/10.1101/2021.10.06.463353
David Joffe
aWAVi Research, Boulder CO
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D S Oakley
aWAVi Research, Boulder CO
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F Arese Lucini
aWAVi Research, Boulder CO
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  • ORCID record for F Arese Lucini
  • For correspondence: francesca.arese@wavimed.com
F. X. Palermo
bUniversity of Colorado School of Medicine, Aurora, CO
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Abstract

Background Peak individual alpha frequencies (IAF) extracted from an EEG exam can provide novel sources of information regarding brain function. This information can help measure and track changes in cognition arising from conditions such as concussion or unhealthy aging.

Objective 1 To validate a method for combining eyes-closed EEG with eyes-closed audio P300 ERP in order to streamline testing times involved in IAF extraction.

Objective 2 To validate age-stratified target ranges of IAF collected in clinic against published research.

Objective 3 To validate the stability of IAF for data collected in routine clinical settings.

Participants Two thousand twenty-five subjects aged 13-90.

Methods EEG with audio P300 was collected as part of a health screening exam for studies through Colorado University, Children’s Hospital Colorado, Boone Heart Institute, WAVi Co., and various clinics alongside other clinical evaluations.

Results (1) No differences were seen between IAF extracted during an eyes-closed resting and the P300 protocol. (2) The age-related AF trends measured in clinic match the age-related trends from previous research. (3) IAF remained stable over the course of 0-2 years in a test-retest dataset.

Conclusion In-clinic measures of peak EEG frequency corroborate the age-related trends of published research taken over the last several decades and IAF. These results also confirm that IAF is a stable trait, making it useful for within-person longitudinal tracking. By following changes in IAF over time, deviations from normal CNS functioning, such as onset or progression of disease, can be monitored.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license.
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Posted October 08, 2021.
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Measurements of EEG Alpha Peak Frequencies Over the Lifespan: Validating Target Ranges on an In-Clinic Platform
David Joffe, D S Oakley, F Arese Lucini, F. X. Palermo
bioRxiv 2021.10.06.463353; doi: https://doi.org/10.1101/2021.10.06.463353
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Measurements of EEG Alpha Peak Frequencies Over the Lifespan: Validating Target Ranges on an In-Clinic Platform
David Joffe, D S Oakley, F Arese Lucini, F. X. Palermo
bioRxiv 2021.10.06.463353; doi: https://doi.org/10.1101/2021.10.06.463353

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