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Comprehensive antibody profiling of mRNA vaccination in children

Yannic C Bartsch, Kerri J St Denis, Paulina Kaplonek, Jaewon Kang, Evan C. Lam, Eva J Farkas, Jameson Davis, Brittany Boribong, Wayne Shreffler, View ORCID ProfileAlejandro B Balazs, Lael M Yonker, Galit Alter
doi: https://doi.org/10.1101/2021.10.07.463592
Yannic C Bartsch
1Ragon Institute of MGH, MIT, and Harvard; Cambridge, MA, USA
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Kerri J St Denis
1Ragon Institute of MGH, MIT, and Harvard; Cambridge, MA, USA
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Paulina Kaplonek
1Ragon Institute of MGH, MIT, and Harvard; Cambridge, MA, USA
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Jaewon Kang
1Ragon Institute of MGH, MIT, and Harvard; Cambridge, MA, USA
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Evan C. Lam
1Ragon Institute of MGH, MIT, and Harvard; Cambridge, MA, USA
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Eva J Farkas
2Massachusetts General Hospital, Mucosal Immunology and Biology Research Center; Boston, MA, USA
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Jameson Davis
2Massachusetts General Hospital, Mucosal Immunology and Biology Research Center; Boston, MA, USA
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Brittany Boribong
2Massachusetts General Hospital, Mucosal Immunology and Biology Research Center; Boston, MA, USA
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Wayne Shreffler
3Food Allergy Center, Massachusetts General Hospital, Division of Pediatric Allergy and Immunology; Boston, Massachusetts
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Alejandro B Balazs
1Ragon Institute of MGH, MIT, and Harvard; Cambridge, MA, USA
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  • ORCID record for Alejandro B Balazs
Lael M Yonker
2Massachusetts General Hospital, Mucosal Immunology and Biology Research Center; Boston, MA, USA
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  • For correspondence: LYONKER@mgh.harvard.edu GALTER@mgh.harvard.edu
Galit Alter
1Ragon Institute of MGH, MIT, and Harvard; Cambridge, MA, USA
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  • For correspondence: LYONKER@mgh.harvard.edu GALTER@mgh.harvard.edu
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Abstract

With the emergence of SARS-CoV-2 variants, fluctuating mask mandates, and school re-openings, increased infections and disease surged among children recently. Thus, there is an urgent need for COVID-19 vaccines for children of all ages. However, whether young children will respond appropriately to mRNA vaccines remains unclear. Here, we deeply profiled the vaccine-induced humoral immune response in 7-11 year old children receiving the mRNA-1273 vaccine. Vaccinated children induced significantly higher antibody titers and functions compared to naturally infected children. Moreover, we observed comparable SARS-CoV-2 titers and neutralizing activity across variants of concern and superior Fcγ-receptor binding and phagocytic antibodies in children compared to vaccinated adults. Our data indicate that mRNA vaccination elicits robust antibody responses and drives superior antibody functionality in children.

One-Sentence Summary mRNA vaccination elicits robust humoral immune responses to SARS-CoV-2 in children 7-11 years of age.

Competing Interest Statement

G.A. is a founder and equity holder of Seromyx Systems, a company developing a platform technology that describes the antibody immune response. G.A. is an employee and equity holder of Leyden Labs, a company developing pandemic prevention therapeutics. G.A.s interests were reviewed and are managed by Massachusetts General Hospital and Partners HealthCare in accordance with their conflict of interest policies. All other authors have declared that no conflicts of interest exist.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted October 09, 2021.
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Comprehensive antibody profiling of mRNA vaccination in children
Yannic C Bartsch, Kerri J St Denis, Paulina Kaplonek, Jaewon Kang, Evan C. Lam, Eva J Farkas, Jameson Davis, Brittany Boribong, Wayne Shreffler, Alejandro B Balazs, Lael M Yonker, Galit Alter
bioRxiv 2021.10.07.463592; doi: https://doi.org/10.1101/2021.10.07.463592
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Comprehensive antibody profiling of mRNA vaccination in children
Yannic C Bartsch, Kerri J St Denis, Paulina Kaplonek, Jaewon Kang, Evan C. Lam, Eva J Farkas, Jameson Davis, Brittany Boribong, Wayne Shreffler, Alejandro B Balazs, Lael M Yonker, Galit Alter
bioRxiv 2021.10.07.463592; doi: https://doi.org/10.1101/2021.10.07.463592

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