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Self-organized tissue mechanics underlie embryonic regulation

Paolo Caldarelli, Alexander Chamolly, Olinda Alegria-Prévot, View ORCID ProfileJerome Gros, View ORCID ProfileFrancis Corson
doi: https://doi.org/10.1101/2021.10.08.463661
Paolo Caldarelli
1Institut Pasteur, Université de Paris, CNRS UMR3738, Developmental and Stem Cell Biology Department, F-75015 Paris, France
2Sorbonne Université, Collège doctoral, F-75005 Paris, France
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Alexander Chamolly
1Institut Pasteur, Université de Paris, CNRS UMR3738, Developmental and Stem Cell Biology Department, F-75015 Paris, France
3Laboratoire de Physique de l’Ecole Normale Supérieure, CNRS, ENS, Université PSL, Sorbonne Université, Université de Paris, 75005 Paris, France
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Olinda Alegria-Prévot
1Institut Pasteur, Université de Paris, CNRS UMR3738, Developmental and Stem Cell Biology Department, F-75015 Paris, France
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Jerome Gros
1Institut Pasteur, Université de Paris, CNRS UMR3738, Developmental and Stem Cell Biology Department, F-75015 Paris, France
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  • For correspondence: jgros@pasteur.fr corson@phys.ens.fr
Francis Corson
3Laboratoire de Physique de l’Ecole Normale Supérieure, CNRS, ENS, Université PSL, Sorbonne Université, Université de Paris, 75005 Paris, France
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  • For correspondence: jgros@pasteur.fr corson@phys.ens.fr
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Abstract

Early amniote development is a highly regulative and self-organized process, capable to adapt to interference through cell-cell interactions, which are widely believed to be mediated by molecules. Analyzing intact and mechanically perturbed avian embryos, we show that the mechanical forces that drive embryogenesis self-organize in an analog of Turing’s molecular reaction-diffusion model, with contractility locally self-activating and the ensuing tension acting as a long-range inhibitor. This mechanical feedback governs the persistent pattern of tissue flows that shape the embryo and steers the concomitant emergence of embryonic territories by modulating gene expression, ensuring the formation of a single embryo under normal conditions, yet allowing the emergence of multiple, well-proportioned embryos upon perturbations. Thus, mechanical forces are a central signal in embryonic self-organization, feeding back onto gene expression to canalize both patterning and morphogenesis.

Competing Interest Statement

The authors have declared no competing interest.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted October 09, 2021.
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Self-organized tissue mechanics underlie embryonic regulation
Paolo Caldarelli, Alexander Chamolly, Olinda Alegria-Prévot, Jerome Gros, Francis Corson
bioRxiv 2021.10.08.463661; doi: https://doi.org/10.1101/2021.10.08.463661
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Self-organized tissue mechanics underlie embryonic regulation
Paolo Caldarelli, Alexander Chamolly, Olinda Alegria-Prévot, Jerome Gros, Francis Corson
bioRxiv 2021.10.08.463661; doi: https://doi.org/10.1101/2021.10.08.463661

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