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Quantitative multiplex immunohistochemistry reveals inter-patient lymphovascular and immune heterogeneity in primary cutaneous melanoma

Julia Femel, Jamie L. Booth, Tina G. Asnaashari, Sancy A. Leachman, Takahiro Tsujikawa, Kevin P. White, View ORCID ProfileYoung H. Chang, Amanda W. Lund
doi: https://doi.org/10.1101/2021.10.08.463675
Julia Femel
1Department of Cell, Developmental, & Cancer Biology, Oregon Health & Science University, Portland, OR
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Jamie L. Booth
1Department of Cell, Developmental, & Cancer Biology, Oregon Health & Science University, Portland, OR
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Tina G. Asnaashari
2Department of Biomedical Engineering and Computational Biology Program, Oregon Health & Science University, Portland, OR, 97239
3OHSU Center for Spatial Systems Biomedicine, Oregon Health & Science University, Portland, OR, 97239
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Sancy A. Leachman
5Department of Dermatology, Oregon Health & Science University, Portland, OR
6Knight Cancer Institute, Oregon Health & Science University, Portland, OR
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Takahiro Tsujikawa
1Department of Cell, Developmental, & Cancer Biology, Oregon Health & Science University, Portland, OR
7Department of Otolaryngology-Head and Neck Surgery, Kyoto Prefectural University of Medicine, Kyoto City, Kyoto, Japan
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Kevin P. White
5Department of Dermatology, Oregon Health & Science University, Portland, OR
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Young H. Chang
2Department of Biomedical Engineering and Computational Biology Program, Oregon Health & Science University, Portland, OR, 97239
3OHSU Center for Spatial Systems Biomedicine, Oregon Health & Science University, Portland, OR, 97239
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  • ORCID record for Young H. Chang
Amanda W. Lund
1Department of Cell, Developmental, & Cancer Biology, Oregon Health & Science University, Portland, OR
2Department of Biomedical Engineering and Computational Biology Program, Oregon Health & Science University, Portland, OR, 97239
3OHSU Center for Spatial Systems Biomedicine, Oregon Health & Science University, Portland, OR, 97239
4Department of Molecular Microbiology & Immunology, Oregon Health & Science University, Portland, OR
5Department of Dermatology, Oregon Health & Science University, Portland, OR
6Knight Cancer Institute, Oregon Health & Science University, Portland, OR
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  • For correspondence: amanda.lund@nyulangone.org
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Article Information

doi 
https://doi.org/10.1101/2021.10.08.463675
History 
  • October 9, 2021.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

Author Information

  1. Julia Femel1,
  2. Jamie L. Booth1,
  3. Tina G. Asnaashari2,3,
  4. Sancy A. Leachman5,6,
  5. Takahiro Tsujikawa1,7,
  6. Kevin P. White5,
  7. Young H. Chang2,3 and
  8. Amanda W. Lund1,2,3,4,5,6,#
  1. 1Department of Cell, Developmental, & Cancer Biology, Oregon Health & Science University, Portland, OR
  2. 2Department of Biomedical Engineering and Computational Biology Program, Oregon Health & Science University, Portland, OR, 97239
  3. 3OHSU Center for Spatial Systems Biomedicine, Oregon Health & Science University, Portland, OR, 97239
  4. 4Department of Molecular Microbiology & Immunology, Oregon Health & Science University, Portland, OR
  5. 5Department of Dermatology, Oregon Health & Science University, Portland, OR
  6. 6Knight Cancer Institute, Oregon Health & Science University, Portland, OR
  7. 7Department of Otolaryngology-Head and Neck Surgery, Kyoto Prefectural University of Medicine, Kyoto City, Kyoto, Japan
  1. ↵#Corresponding Author Amanda W. Lund, Department of Cell, Developmental & Cancer Biology, Knight Cancer Institute, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd Portland, OR 97239, e: amanda.lund{at}nyulangone.org
  • AWL: Ronald O. Perelman Department of Dermatology, Perlmutter Cancer Center, NYU Langone Health 522 First Ave, New York, NY 10016, p: 212-263-5070

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Posted October 09, 2021.
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Quantitative multiplex immunohistochemistry reveals inter-patient lymphovascular and immune heterogeneity in primary cutaneous melanoma
Julia Femel, Jamie L. Booth, Tina G. Asnaashari, Sancy A. Leachman, Takahiro Tsujikawa, Kevin P. White, Young H. Chang, Amanda W. Lund
bioRxiv 2021.10.08.463675; doi: https://doi.org/10.1101/2021.10.08.463675
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Quantitative multiplex immunohistochemistry reveals inter-patient lymphovascular and immune heterogeneity in primary cutaneous melanoma
Julia Femel, Jamie L. Booth, Tina G. Asnaashari, Sancy A. Leachman, Takahiro Tsujikawa, Kevin P. White, Young H. Chang, Amanda W. Lund
bioRxiv 2021.10.08.463675; doi: https://doi.org/10.1101/2021.10.08.463675

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