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Membrane phosphoinositides stabilize GPCR-arrestin complexes and offer temporal control of complex assembly and dynamics
View ORCID ProfileJohn Janetzko, Ryoji Kise, Benjamin Barsi-Ryne, Dirk H. Siepe, View ORCID ProfileFranziska M. Heydenreich, Matthieu Masureel, Kouki Kawakami, K. Christopher Garcia, Mark von Zastrow, View ORCID ProfileAsuka Inoue, Brian K. Kobilka
doi: https://doi.org/10.1101/2021.10.09.463790
John Janetzko
1Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA
Ryoji Kise
2Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3, Aoba, Aramaki, Aoba-ku, Sendai, Miyagi, 980-8578 Japan
Benjamin Barsi-Ryne
3Department of Cellular and Molecular Pharmacology, University of California, San Francisco, School of Medicine, San Francisco, CA, USA
4Department of Psychiatry, University of California, San Francisco, School of Medicine, San Francisco, CA, USA
Dirk H. Siepe
1Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA
5Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA
6Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA, USA
Franziska M. Heydenreich
1Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA
Matthieu Masureel
1Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA
7Department of Structural Biology, Genentech Inc., South San Francisco, CA 94080, USA
Kouki Kawakami
2Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3, Aoba, Aramaki, Aoba-ku, Sendai, Miyagi, 980-8578 Japan
K. Christopher Garcia
1Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA
5Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA
6Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA, USA
Mark von Zastrow
3Department of Cellular and Molecular Pharmacology, University of California, San Francisco, School of Medicine, San Francisco, CA, USA
4Department of Psychiatry, University of California, San Francisco, School of Medicine, San Francisco, CA, USA
Asuka Inoue
2Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3, Aoba, Aramaki, Aoba-ku, Sendai, Miyagi, 980-8578 Japan
Brian K. Kobilka
1Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA
Article usage
Posted October 10, 2021.
Membrane phosphoinositides stabilize GPCR-arrestin complexes and offer temporal control of complex assembly and dynamics
John Janetzko, Ryoji Kise, Benjamin Barsi-Ryne, Dirk H. Siepe, Franziska M. Heydenreich, Matthieu Masureel, Kouki Kawakami, K. Christopher Garcia, Mark von Zastrow, Asuka Inoue, Brian K. Kobilka
bioRxiv 2021.10.09.463790; doi: https://doi.org/10.1101/2021.10.09.463790
Membrane phosphoinositides stabilize GPCR-arrestin complexes and offer temporal control of complex assembly and dynamics
John Janetzko, Ryoji Kise, Benjamin Barsi-Ryne, Dirk H. Siepe, Franziska M. Heydenreich, Matthieu Masureel, Kouki Kawakami, K. Christopher Garcia, Mark von Zastrow, Asuka Inoue, Brian K. Kobilka
bioRxiv 2021.10.09.463790; doi: https://doi.org/10.1101/2021.10.09.463790
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