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Interactions between natural selection and recombination shape the genomic landscape of introgression

View ORCID ProfileMaud Duranton, John Pool
doi: https://doi.org/10.1101/2021.10.12.462572
Maud Duranton
1Laboratory of Genetics, University of Wisconsin-Madison, Madison, WI, USA
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  • For correspondence: durantonmaud@gmail.com
John Pool
1Laboratory of Genetics, University of Wisconsin-Madison, Madison, WI, USA
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Abstract

Hybridization between lineages that have not reached complete reproductive isolation appears more and more like a common phenomenon. Indeed, speciation genomics studies have now extensively shown that many species’ genomes have hybrid ancestry. However, genomic patterns of introgression are often heterogeneous across the genome. In many organisms, a positive correlation between introgression levels and recombination rate has been observed. It is usually explained by the purging of deleterious introgressed material due to incompatibilities. However, the opposite relationship was observed in a North American population of Drosophila melanogaster with admixed European and African ancestry. In order to explore how directional and epistatic selection can impact the relationship between introgression and recombination, we performed forward simulations of whole D. melanogaster genomes reflecting the North American population’s history. Our results revealed that the simplest models of positive selection often yield negative correlations between introgression and recombination such as the one observed in D. melanogaster. We also confirmed that incompatibilities tend to produce positive introgression-recombination correlations. And yet, we identify parameter space under each model where the predicted correlation is reversed. These findings deepen our understanding of the evolutionary forces that may shape patterns of ancestry across genomes, and they strengthen the foundation for future studies aimed at estimating genome-wide parameters of selection in admixed populations.

Competing Interest Statement

The authors have declared no competing interest.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted October 13, 2021.
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Interactions between natural selection and recombination shape the genomic landscape of introgression
Maud Duranton, John Pool
bioRxiv 2021.10.12.462572; doi: https://doi.org/10.1101/2021.10.12.462572
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Interactions between natural selection and recombination shape the genomic landscape of introgression
Maud Duranton, John Pool
bioRxiv 2021.10.12.462572; doi: https://doi.org/10.1101/2021.10.12.462572

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