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Weak representation of awake/sleep states by local field potentials in aged mice

View ORCID ProfileDaichi Konno, Yuji Ikegaya, Takuya Sasaki
doi: https://doi.org/10.1101/2021.10.13.464191
Daichi Konno
1Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan
2Laboratory of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan
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Yuji Ikegaya
1Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan
3Institute for AI and Beyond, The University of Tokyo, Tokyo 113-0033, Japan
4Center for Information and Neural Networks, National Institute of Information and Communications Technology, Suita City, Osaka, 565-0871, Japan
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Takuya Sasaki
1Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan
5Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aramaki-Aoba, Aoba-Ku, Sendai 980-8578, Japan
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  • For correspondence: takuya.sasaki.b4@tohoku.ac.jp
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Abstract

Senescence affects various aspects of sleep, and it remains unclear how sleep-related neuronal network activity is altered by senescence. Here, we recorded local field potential signals from multiple brain regions covering the forebrain in young (10-week-old) and aged (2-year-old) mice. Interregional LFP correlations across these brain regions showed smaller differences between awake and sleep states in aged mice. Multivariate analyses with machine learning algorithms with uniform manifold approximation and projection (UMAP) and robust continuous clustering (RCC) demonstrated that these LFP correlational patterns in aged mice less represented awake/sleep states than those in young mice. By housing aged mice in an enriched environment, the LFP patterns were restored to those observed in young mice. Our results demonstrate senescence-induced changes in neuronal activity at the network level and provide insight into the prevention of pathological symptoms associated with sleep disturbance in senescence.

Competing Interest Statement

The authors have declared no competing interest.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted October 14, 2021.
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Weak representation of awake/sleep states by local field potentials in aged mice
Daichi Konno, Yuji Ikegaya, Takuya Sasaki
bioRxiv 2021.10.13.464191; doi: https://doi.org/10.1101/2021.10.13.464191
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Weak representation of awake/sleep states by local field potentials in aged mice
Daichi Konno, Yuji Ikegaya, Takuya Sasaki
bioRxiv 2021.10.13.464191; doi: https://doi.org/10.1101/2021.10.13.464191

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