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Neuronal hemoglobin induces α-synuclein cleavage and loss of dopaminergic neurons

Santulli Chiara, Bon Carlotta, De Cecco Elena, Codrich Marta, Narkiewicz Joanna, Parisse Pietro, Perissinotto Fabio, Claudio Santoro, Francesca Persichetti, Legname Giuseppe, Stefano Espinoza, Gustincich Stefano
doi: https://doi.org/10.1101/2021.10.13.464204
Santulli Chiara
1Area of Neuroscience, Scuola Internazionale Superiore di Studi Avanzati (SISSA), Trieste, Italy
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Bon Carlotta
2Central RNA Laboratory, Istituto Italiano di Tecnologia (IIT), Genova, Italy
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De Cecco Elena
1Area of Neuroscience, Scuola Internazionale Superiore di Studi Avanzati (SISSA), Trieste, Italy
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Codrich Marta
1Area of Neuroscience, Scuola Internazionale Superiore di Studi Avanzati (SISSA), Trieste, Italy
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Narkiewicz Joanna
1Area of Neuroscience, Scuola Internazionale Superiore di Studi Avanzati (SISSA), Trieste, Italy
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Parisse Pietro
3ELETTRA Synchrotron Light Source, Trieste, Italy
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Perissinotto Fabio
3ELETTRA Synchrotron Light Source, Trieste, Italy
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Claudio Santoro
4Department of Health Sciences and Research Center on Autoimmune and Allergic Diseases (CAAD), University of Piemonte Orientale (UPO), Novara, Italy
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Francesca Persichetti
4Department of Health Sciences and Research Center on Autoimmune and Allergic Diseases (CAAD), University of Piemonte Orientale (UPO), Novara, Italy
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Legname Giuseppe
1Area of Neuroscience, Scuola Internazionale Superiore di Studi Avanzati (SISSA), Trieste, Italy
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Stefano Espinoza
2Central RNA Laboratory, Istituto Italiano di Tecnologia (IIT), Genova, Italy
4Department of Health Sciences and Research Center on Autoimmune and Allergic Diseases (CAAD), University of Piemonte Orientale (UPO), Novara, Italy
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  • For correspondence: stefano.gustincich@iit.it stefano.espinoza@iit.it
Gustincich Stefano
1Area of Neuroscience, Scuola Internazionale Superiore di Studi Avanzati (SISSA), Trieste, Italy
2Central RNA Laboratory, Istituto Italiano di Tecnologia (IIT), Genova, Italy
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  • For correspondence: stefano.gustincich@iit.it stefano.espinoza@iit.it
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Article Information

doi 
https://doi.org/10.1101/2021.10.13.464204
History 
  • October 14, 2021.

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  • You are currently viewing Version 1 of this article (October 14, 2021 - 16:32).
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Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Santulli Chiara1,*,
  2. Bon Carlotta2,*,
  3. De Cecco Elena1,
  4. Codrich Marta1,
  5. Narkiewicz Joanna1,
  6. Parisse Pietro3,
  7. Perissinotto Fabio3,
  8. Claudio Santoro4,
  9. Francesca Persichetti4,
  10. Legname Giuseppe1,
  11. Stefano Espinoza2,4,# and
  12. Gustincich Stefano1,2,#
  1. 1Area of Neuroscience, Scuola Internazionale Superiore di Studi Avanzati (SISSA), Trieste, Italy
  2. 2Central RNA Laboratory, Istituto Italiano di Tecnologia (IIT), Genova, Italy
  3. 3ELETTRA Synchrotron Light Source, Trieste, Italy
  4. 4Department of Health Sciences and Research Center on Autoimmune and Allergic Diseases (CAAD), University of Piemonte Orientale (UPO), Novara, Italy
  1. ↵#Corresponding author: Stefano Gustincich, Deputy Director for Life Sciences, Director – Central RNA Laboratory, Istituto Italiano di Tecnologia (IIT), via Melen 83, Genova (GE) 16152 - Italy, Tel: +39-010-71781-447, e-mail: stefano.gustincich{at}iit.it, Correspondence may also be addressed to: Stefano Espinoza, Central RNA Laboratory, Istituto Italiano di Tecnologia (IIT), via Melen 83, Genova (GE) 16152 – Italy, e-mail: stefano.espinoza{at}iit.it
  1. ↵* equally contributed to the paper

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Neuronal hemoglobin induces α-synuclein cleavage and loss of dopaminergic neurons
Santulli Chiara, Bon Carlotta, De Cecco Elena, Codrich Marta, Narkiewicz Joanna, Parisse Pietro, Perissinotto Fabio, Claudio Santoro, Francesca Persichetti, Legname Giuseppe, Stefano Espinoza, Gustincich Stefano
bioRxiv 2021.10.13.464204; doi: https://doi.org/10.1101/2021.10.13.464204
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Neuronal hemoglobin induces α-synuclein cleavage and loss of dopaminergic neurons
Santulli Chiara, Bon Carlotta, De Cecco Elena, Codrich Marta, Narkiewicz Joanna, Parisse Pietro, Perissinotto Fabio, Claudio Santoro, Francesca Persichetti, Legname Giuseppe, Stefano Espinoza, Gustincich Stefano
bioRxiv 2021.10.13.464204; doi: https://doi.org/10.1101/2021.10.13.464204

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