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Spatial proteogenomics reveals distinct and evolutionarily-conserved hepatic macrophage niches
View ORCID ProfileMartin Guilliams, Johnny Bonnardel, Birthe Haest, Bart Vanderborght, Anna Bujko, Liesbet Martens, Tinne Thoné, Robin Browaeys, Federico F. De Ponti, Anneleen Remmerie, Camille Wagner, Bavo Vanneste, Christian Zwicker, Tineke Vanhalewyn, Amanda Gonçalves, Saskia Lippens, Bert Devriendt, Eric Cox, Giuliano Ferrero, Valerie Wittamer, Andy Willaert, Suzanne J.F. Kaptein, Johan Neyts, Kai Dallmeier, Peter Geldhof, Stijn Casaert, Bart Deplancke, Peter ten Dijke, Anne Hoorens, Aude Vanlander, Frederik Berrevoet, Yves Van Nieuwenhove, Yvan Saeys, Wouter Saelens, Hans Van Vlierberghe, Lindsey Devisscher, View ORCID ProfileCharlotte L. Scott
doi: https://doi.org/10.1101/2021.10.15.464432
Martin Guilliams
1Laboratory of Myeloid Cell Biology in Tissue Homeostasis and Regeneration, VIB-UGent Center for Inflammation Research, Technologiepark-Zwijnaarde 71, Ghent 9052, Belgium
2Department of Biomedical Molecular Biology, Faculty of Science, Ghent University, Ghent, Belgium
Johnny Bonnardel
1Laboratory of Myeloid Cell Biology in Tissue Homeostasis and Regeneration, VIB-UGent Center for Inflammation Research, Technologiepark-Zwijnaarde 71, Ghent 9052, Belgium
2Department of Biomedical Molecular Biology, Faculty of Science, Ghent University, Ghent, Belgium
Birthe Haest
1Laboratory of Myeloid Cell Biology in Tissue Homeostasis and Regeneration, VIB-UGent Center for Inflammation Research, Technologiepark-Zwijnaarde 71, Ghent 9052, Belgium
2Department of Biomedical Molecular Biology, Faculty of Science, Ghent University, Ghent, Belgium
Bart Vanderborght
3Hepatology Research Unit, Department Internal Medicine and Pediatrics, Liver research Center, Ghent University, Belgium
4Department of Basic and Applied Medical Sciences, Faculty of Medicine and Health Sciences, Ghent University, Belgium
Anna Bujko
2Department of Biomedical Molecular Biology, Faculty of Science, Ghent University, Ghent, Belgium
5Laboratory of Myeloid Cell Biology in Tissue Damage and Inflammation, VIB-UGent Center for Inflammation Research, Technologiepark-Zwijnaarde 71, Ghent 9052, Belgium
Liesbet Martens
1Laboratory of Myeloid Cell Biology in Tissue Homeostasis and Regeneration, VIB-UGent Center for Inflammation Research, Technologiepark-Zwijnaarde 71, Ghent 9052, Belgium
2Department of Biomedical Molecular Biology, Faculty of Science, Ghent University, Ghent, Belgium
5Laboratory of Myeloid Cell Biology in Tissue Damage and Inflammation, VIB-UGent Center for Inflammation Research, Technologiepark-Zwijnaarde 71, Ghent 9052, Belgium
Tinne Thoné
1Laboratory of Myeloid Cell Biology in Tissue Homeostasis and Regeneration, VIB-UGent Center for Inflammation Research, Technologiepark-Zwijnaarde 71, Ghent 9052, Belgium
2Department of Biomedical Molecular Biology, Faculty of Science, Ghent University, Ghent, Belgium
5Laboratory of Myeloid Cell Biology in Tissue Damage and Inflammation, VIB-UGent Center for Inflammation Research, Technologiepark-Zwijnaarde 71, Ghent 9052, Belgium
Robin Browaeys
6Data Mining and Modelling for Biomedicine, VIB-UGent Center for Inflammation Research, Technologiepark-Zwijnaarde 71, Ghent 9052, Belgium
7Department of Applied Mathematics, Computer Science and Statistics, Faculty of Science, Ghent University, Ghent, Belgium
Federico F. De Ponti
2Department of Biomedical Molecular Biology, Faculty of Science, Ghent University, Ghent, Belgium
5Laboratory of Myeloid Cell Biology in Tissue Damage and Inflammation, VIB-UGent Center for Inflammation Research, Technologiepark-Zwijnaarde 71, Ghent 9052, Belgium
Anneleen Remmerie
2Department of Biomedical Molecular Biology, Faculty of Science, Ghent University, Ghent, Belgium
5Laboratory of Myeloid Cell Biology in Tissue Damage and Inflammation, VIB-UGent Center for Inflammation Research, Technologiepark-Zwijnaarde 71, Ghent 9052, Belgium
Camille Wagner
1Laboratory of Myeloid Cell Biology in Tissue Homeostasis and Regeneration, VIB-UGent Center for Inflammation Research, Technologiepark-Zwijnaarde 71, Ghent 9052, Belgium
2Department of Biomedical Molecular Biology, Faculty of Science, Ghent University, Ghent, Belgium
Bavo Vanneste
1Laboratory of Myeloid Cell Biology in Tissue Homeostasis and Regeneration, VIB-UGent Center for Inflammation Research, Technologiepark-Zwijnaarde 71, Ghent 9052, Belgium
2Department of Biomedical Molecular Biology, Faculty of Science, Ghent University, Ghent, Belgium
5Laboratory of Myeloid Cell Biology in Tissue Damage and Inflammation, VIB-UGent Center for Inflammation Research, Technologiepark-Zwijnaarde 71, Ghent 9052, Belgium
Christian Zwicker
2Department of Biomedical Molecular Biology, Faculty of Science, Ghent University, Ghent, Belgium
5Laboratory of Myeloid Cell Biology in Tissue Damage and Inflammation, VIB-UGent Center for Inflammation Research, Technologiepark-Zwijnaarde 71, Ghent 9052, Belgium
Tineke Vanhalewyn
1Laboratory of Myeloid Cell Biology in Tissue Homeostasis and Regeneration, VIB-UGent Center for Inflammation Research, Technologiepark-Zwijnaarde 71, Ghent 9052, Belgium
2Department of Biomedical Molecular Biology, Faculty of Science, Ghent University, Ghent, Belgium
5Laboratory of Myeloid Cell Biology in Tissue Damage and Inflammation, VIB-UGent Center for Inflammation Research, Technologiepark-Zwijnaarde 71, Ghent 9052, Belgium
Amanda Gonçalves
2Department of Biomedical Molecular Biology, Faculty of Science, Ghent University, Ghent, Belgium
8VIB BioImaging Core, VIB-UGent Center for Inflammation Research, Technologiepark-Zwijnaarde 71, Ghent 9052, Belgium
Saskia Lippens
2Department of Biomedical Molecular Biology, Faculty of Science, Ghent University, Ghent, Belgium
8VIB BioImaging Core, VIB-UGent Center for Inflammation Research, Technologiepark-Zwijnaarde 71, Ghent 9052, Belgium
Bert Devriendt
9Laboratory of Immunology, Department Virology Parasitology Immunology and Comparative Physiology, Faculty of Veterinary Medicine, Ghent University, Belgium
Eric Cox
9Laboratory of Immunology, Department Virology Parasitology Immunology and Comparative Physiology, Faculty of Veterinary Medicine, Ghent University, Belgium
Giuliano Ferrero
10Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire (IRIBHM), Université Libre de Bruxelles (ULB), Brussels, Belgium
Valerie Wittamer
10Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire (IRIBHM), Université Libre de Bruxelles (ULB), Brussels, Belgium
11ULB Institute of Neuroscience (UNI), Université Libre de Bruxelles (ULB), Brussels, Belgium
12WELBIO, Université Libre de Bruxelles (ULB), Brussels, Belgium
Andy Willaert
13Center for Medical Genetics Ghent, Department of Biomolecular Medicine, Ghent University, Ghent, Belgium
Suzanne J.F. Kaptein
14KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Molecular Vaccinology and Vaccine Discovery, Leuven, Belgium
Johan Neyts
14KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Molecular Vaccinology and Vaccine Discovery, Leuven, Belgium
Kai Dallmeier
14KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Molecular Vaccinology and Vaccine Discovery, Leuven, Belgium
Peter Geldhof
15Laboratory of Parasitology, Faculty of Veterinary Medicine, Ghent University, Ghent, Belgium
Stijn Casaert
15Laboratory of Parasitology, Faculty of Veterinary Medicine, Ghent University, Ghent, Belgium
Bart Deplancke
16Laboratory of Systems Biology and Genetics, Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland
17Swiss Institute of Bioinformatics (SIB), Lausanne, Switzerland
Peter ten Dijke
18Oncode Institute, Department of Molecular Cell Biology and Center for Cancer Genomics, Leiden Medical Center, Leiden, Netherlands
Anne Hoorens
19Department of Pathology, Ghent University Hospital, Ghent 9000, Belgium
Aude Vanlander
20Department of General and Hepatopancreatobiliary Surgery and Liver Transplantation, Ghent University Hospital, Ghent 9000, Belgium
Frederik Berrevoet
20Department of General and Hepatopancreatobiliary Surgery and Liver Transplantation, Ghent University Hospital, Ghent 9000, Belgium
Yves Van Nieuwenhove
21Department of Human Structure and Repair, Ghent University Hospital, Ghent 9000, Belgium
Yvan Saeys
6Data Mining and Modelling for Biomedicine, VIB-UGent Center for Inflammation Research, Technologiepark-Zwijnaarde 71, Ghent 9052, Belgium
7Department of Applied Mathematics, Computer Science and Statistics, Faculty of Science, Ghent University, Ghent, Belgium
Wouter Saelens
16Laboratory of Systems Biology and Genetics, Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland
17Swiss Institute of Bioinformatics (SIB), Lausanne, Switzerland
Hans Van Vlierberghe
3Hepatology Research Unit, Department Internal Medicine and Pediatrics, Liver research Center, Ghent University, Belgium
Lindsey Devisscher
4Department of Basic and Applied Medical Sciences, Faculty of Medicine and Health Sciences, Ghent University, Belgium
Charlotte L. Scott
2Department of Biomedical Molecular Biology, Faculty of Science, Ghent University, Ghent, Belgium
5Laboratory of Myeloid Cell Biology in Tissue Damage and Inflammation, VIB-UGent Center for Inflammation Research, Technologiepark-Zwijnaarde 71, Ghent 9052, Belgium
Posted October 16, 2021.
Spatial proteogenomics reveals distinct and evolutionarily-conserved hepatic macrophage niches
Martin Guilliams, Johnny Bonnardel, Birthe Haest, Bart Vanderborght, Anna Bujko, Liesbet Martens, Tinne Thoné, Robin Browaeys, Federico F. De Ponti, Anneleen Remmerie, Camille Wagner, Bavo Vanneste, Christian Zwicker, Tineke Vanhalewyn, Amanda Gonçalves, Saskia Lippens, Bert Devriendt, Eric Cox, Giuliano Ferrero, Valerie Wittamer, Andy Willaert, Suzanne J.F. Kaptein, Johan Neyts, Kai Dallmeier, Peter Geldhof, Stijn Casaert, Bart Deplancke, Peter ten Dijke, Anne Hoorens, Aude Vanlander, Frederik Berrevoet, Yves Van Nieuwenhove, Yvan Saeys, Wouter Saelens, Hans Van Vlierberghe, Lindsey Devisscher, Charlotte L. Scott
bioRxiv 2021.10.15.464432; doi: https://doi.org/10.1101/2021.10.15.464432
Spatial proteogenomics reveals distinct and evolutionarily-conserved hepatic macrophage niches
Martin Guilliams, Johnny Bonnardel, Birthe Haest, Bart Vanderborght, Anna Bujko, Liesbet Martens, Tinne Thoné, Robin Browaeys, Federico F. De Ponti, Anneleen Remmerie, Camille Wagner, Bavo Vanneste, Christian Zwicker, Tineke Vanhalewyn, Amanda Gonçalves, Saskia Lippens, Bert Devriendt, Eric Cox, Giuliano Ferrero, Valerie Wittamer, Andy Willaert, Suzanne J.F. Kaptein, Johan Neyts, Kai Dallmeier, Peter Geldhof, Stijn Casaert, Bart Deplancke, Peter ten Dijke, Anne Hoorens, Aude Vanlander, Frederik Berrevoet, Yves Van Nieuwenhove, Yvan Saeys, Wouter Saelens, Hans Van Vlierberghe, Lindsey Devisscher, Charlotte L. Scott
bioRxiv 2021.10.15.464432; doi: https://doi.org/10.1101/2021.10.15.464432
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